DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	517	Identity:	182/517 - (35%)
Similarity:	272/517 - (52%)	Gaps:	56/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STLALVAFVLW-AAFLRYLPKILNFLRLQRFAKTLPGPTIG-------ELIANVKKGEILNWLKE 58
            ::|.|...:.| .||..      |:.||:.|    |.|...       .::.|.::|  |..|.|
Mouse    27 ASLFLARILTWICAFYD------NYCRLRCF----PEPPSRHWFWGHMSMVKNNEEG--LQLLTE 79

  Fly    59 LREKHGPVFRIWFGKDLMVM-FTDPEDIKQLLGNNQLLTKSRN--YELLEPWLGKGLLTNGGESW 120
            ...:...|...|.|....:: ...|:.|..:|..:..:.....  |..|:||||.|||.:.||.|
Mouse    80 RSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQASAAVAPKEMIFYGFLKPWLGDGLLVSAGEKW 144

  Fly   121 HRRRKLLTPGFHFRILSEFKEPMEENCRIL---VRRLRTKANGESFDIYPYITLFALDAICETAM 182
            .|.|.||||.|||.||..:.:...::..|:   .:||.||... ..|:..:|:|..||::.....
Mouse   145 SRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTKGTA-CLDMLEHISLMTLDSLQNCVF 208

  Fly   183 GIKKHAQLQSDSEYVQAVQSICRVM---HKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNR 244
            ....:.| :|.|||:.|:|.:..::   |.|.|.:   |:..:..|..|:....|..::|:.|:.
Mouse   209 SFDSNCQ-ESPSEYIAAIQELSSLIVKRHHQPFLY---LDFLYYCTADGRRFRKACDLVHNFTDA 269

  Fly   245 VIRLRREQL-IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEG 308
            |||.||..| .|..:|:.....:     .:.|.|:|:|||.:.|.|.||||.|||.|.|||||.|
Mouse   270 VIRERRRTLSSQNLDEFLKSKTK-----SKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGG 329

  Fly   309 HDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLRIYPS 364
            ||||:||:::.|..|:::|:.|:|..:|..| |.|||.:        .:|:|...|||:||::|.
Mouse   330 HDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLTMCIKESLRLHPP 394

  Fly   365 VPFFSRKVLED--LEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAF 426
            |...||...:|  |..|:: :|||......|:.:|.:|:.:||||.:||.|| ..|.::..|.||
Mouse   395 VTVISRCCTQDVVLPDGRV-IPKGTDCVISIFGVHHNPEVWPDPEVYDPFRFDPENPQKRSPLAF 458

  Fly   427 AAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP-DKDHQPKPLAELVTKSGNGIRLRILP 487
            ..|||||||||||.|||.|:|.:||:.|..:|.|| ||:.:.||  ||:.::..|:.||:.|
Mouse   459 IPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKP--ELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	165/463 (36%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	170/477 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650