DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp-13A8

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_496115.1	Gene:	cyp-13A8 / 188358	WormBaseID:	WBGene00011674	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	116/508 - (22%)
Similarity:	210/508 - (41%)	Gaps:	79/508 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LPGPTIGELIANVKKGEIL-----------NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQL 88
            ||||....:..  |.|.:|           .|.||    :|.::....|...:::.:||:.::::
Worm    26 LPGPWGVPIFG--KAGAMLEDSFPPGYTLQKWTKE----YGKIYGFTEGMQKVMVISDPDLVQEI 84

  Fly    89 LGN--NQLLTKSRNYELLEPWLGKGLLTNG--GESWHRRRKLLTPGFHFRILSEFKEPMEENCRI 149
            |..  :....:..|....:|...|.:...|  |..|.|.|.:..|.|....:.:....||::.:.
Worm    85 LVKQYDNFYGRKHNPVQGDPDKDKDIHIVGAQGFRWKRLRTITAPAFSNGSIKKVLTTMEDSTQE 149

  Fly   150 LVRRLRTKA-NGESFDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQ--AVQSICRVMHKQS 211
            |:::||.:: ||::.:::.:...:..|.|...|||       |.||:..:  .::.:........
Worm   150 LMKKLREESENGKAVNMHLFYQEYTFDVISRVAMG-------QPDSQMFKNPLLKDVKGFFEHNR 207

  Fly   212 FSFWQRLNVF--------FKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDD 268
            :..|.....|        :...|.||.......|:.......:..|..|...::.......|..|
Worm   208 WQIWMFSGGFPFAVSFLKWLFIKVGKFGAGPFIVVQKSVTDAVMSRIAQREADKKHGVEPGEAAD 272

  Fly   269 VGAKRRLAFLDMLLLTQME-----------------GGAELSDTDIREEVDTFMFEGHDTTSSAI 316
                    ::||.|..:.|                 ...:|:..:|..:...|:..|.|||:.::
Worm   273 --------YIDMFLNARAEVEHFGESNDEFHKSSSYNNRQLTTQEIISQCFVFLVAGFDTTAISL 329

  Fly   317 AFALSLLSKNPDVQQRAFEEA------SELEGREKESMPYLEAVIKETLRIYPSVPFF-SRKVLE 374
            ::....|:.||.:|.:..:|.      .|:...:...:.|::.||||:||::|...|. ||:.:.
Worm   330 SYVTYFLALNPKIQSKLQDEVDKECPNDEITFDQLSKLKYMDNVIKESLRLFPFASFANSRRCMR 394

  Fly   375 DLEVGKLTVPKGASISCLIYMLHRDPKNF--PDPERFDPDRFLVNEKQMHP-FAFAAFSAGPRNC 436
            :..:|:..|..|..:....:.||.| ||.  .|.|.|.|:|:   :..:.| .|:.:|.||||.|
Worm   395 NTVIGEQIVEAGVDVMIDTWTLHHD-KNVWGNDVEEFKPERW---DSPLTPQQAYLSFGAGPRVC 455

  Fly   437 IGQKFAMLELKTSLAMLLRSYRFLPD-KDHQPKPLAELVTKSGNGIRLRILPR 488
            :|.:||:||.|..|:.:|:.|.|..: |...|..|....|.....:.|.:.||
Worm   456 LGMRFALLEQKGLLSHILKKYTFETNAKTQLPIKLVGRATARPENLFLSLKPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	111/487 (23%)
cyp-13A8	NP_496115.1	p450	27..503	CDD:278495	112/500 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810