Protein Alignment Cyp4s3 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 139/540 - (25%)
• Similarity: 236/540 - (43%)
• Gaps: 107/540 - (19%)

  Fly     1 MSTL--ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTI----GEL------IANVKKGEIL 53
            :||:  .::.|:.::.:.|:.     ..:| |.:..:|||.:    |.|      ::.:...:..
 Worm     6 ISTIFFTIITFISYSIWRRHA-----IFKL-RSSIGIPGPPVHWLWGNLNIIKDRVSRLGYNDTT 64

  Fly    54 NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQ----------------LLGNNQLLTKSRNYE 102
            .|...|..|:||:|.::.|..|.:..::.||||:                :.|.|||     |..
 Worm    65 QWHPTLHTKYGPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQL-----NQS 124

  Fly   103 LLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTK-ANGESFDIY 166
            ||:.....|        |...|..:.|.|....:....|.:.....|.:..|:.| ::|:.:||:
 Worm   125 LLQNTYATG--------WKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIF 181

  Fly   167 PYITLFALDAICETAMGIKKHAQL-QSDSEYVQAVQSICRVMHKQSFS------------FWQRL 218
            ......:||.|.:.|..|..:.|. ::|..||||.:.:..|..|:|:.            .|:.|
 Worm   182 ENFQSLSLDIIGKCAFAIDSNCQRDRTDLFYVQARKFVGAVDLKKSWILPVSLILPELSWLWRFL 246

  Fly   219 NVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDML-L 282
               :|.:.........:|.|.|..:|    ||          ..|...|..         |:| |
 Worm   247 ---YKFSDLSAAELPLVKGLVDLYDR----RR----------AGEGGNDST---------DLLNL 285

  Fly   283 LTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE---ASELEGRE 344
            |.:.|...:::..::.|....|:..|::|||:|:.|:..||::.|.|||:.:||   ..|..|..
 Worm   286 LIRRETIGKMTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENAGLN 350

  Fly   345 KES---MPYLEAVIKETLRIYPSVPFFSRKV-LEDLEVGKLTVPKGASISCLIYMLHRDPKNFPD 405
            .:|   |.||:.|.||:||.||....|:.:| |.|:.:.....|:.:::....|.:||:|.|:..
 Worm   351 YDSIHNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANWES 415

  Fly   406 PERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYR--FLPDKDHQPK 468
            |:.|.|:||...|::.....:..|..|||.|:|.:||.:|.||::|.||.::.  .:|.   .|.
 Worm   416 PDEFQPERFENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLVPG---DPP 477

  Fly   469 PLAELVTKSGNGIRLRILPR 488
            .:.|.     ||:..|  ||
 Worm   478 MIPET-----NGVIFR--PR 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	122/458 (27%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	126/467 (27%)