DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp-37A1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_496939.2	Gene:	cyp-37A1 / 175053	WormBaseID:	WBGene00008499	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	190/535 - (35%)
Similarity:	267/535 - (49%)	Gaps:	82/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNF----LRLQRFAKTLPGPTIGELIANVKKG---------EILNW 55
            ||||  |::..|  .|.|||.|    :||......:.||....|:....:.         ::.||
Worm     8 LALV--VIYVVF--NLSKILKFVKERMRLYHLMSKIDGPLALPLLGTTFQFKMDPVEFALQLYNW 68

  Fly    56 LKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESW 120
            ..|...|...:...|.|...||:...||..|::|.:|.|:.||..|::..||||.|||...||.|
Worm    69 GLEYSTKGSSLAAFWMGPYPMVIVLTPEANKKVLESNALINKSSEYDIFLPWLGTGLLLASGEKW 133

  Fly   121 HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRT---KANGESFDIYPYITLFALDAICETAM 182
            ..|||::||.|||.:|.:|:........||:.::..   |.:..:.|.:|||...|||.||||||
Worm   134 RGRRKMMTPSFHFNVLIDFQVVFNSQSMILLEQIENAAKKTDDSTIDAFPYIKRCALDIICETAM 198

  Fly   183 GIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFW-----------------QRLNVFFKHTK---P 227
            |....||......||.||..:..:..|.....|                 :.|::....||   .
Worm   199 GTTVSAQTNHTHPYVVAVNEMNSLAFKYQRMPWLWIKPIRQLIGYEADFQRNLDIVTSFTKKVID 263

  Fly   228 GKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAEL 292
            .|.||      ||||:.::      :::|.::.|              ||||||:..:.|||  |
Worm   264 RKLRE------HDETDGMV------VVEEESKKK--------------AFLDMLIEKKEEGG--L 300

  Fly   293 SDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL-EGREKE-------SMP 349
            ...||||||||||||||||||:.|.::|..|:..|:.|::..||..|: ||..:|       .|.
Worm   301 GYEDIREEVDTFMFEGHDTTSAGIGWSLWCLANCPEYQKKCHEELDEIFEGTSRECSVEDLKKMK 365

  Fly   350 YLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF 414
            |||..:||.||:.||||..:|.|.|::|:....:|||.|:......:..:|:.||:.|.|||:||
Worm   366 YLEKCVKEALRMRPSVPQMARSVEEEVEIDGKILPKGCSVMISPAFIQNNPRTFPNHEVFDPERF 430

  Fly   415 LVNEKQM---HPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKD-HQPKPLAELVT 475
              ||.::   |.:|:..|||||||||||||||.|.||.::.:||.:....|.. .:..||.|.:|
Worm   431 --NEDEISKRHAYAYIPFSAGPRNCIGQKFAMQEEKTVISWVLRRFHIHTDIGLLENMPLPETIT 493

  Fly   476 KSGNGIRLRILPRDE 490
            :...|..|:...|.:
Worm   494 RPSLGFPLKFTVRQQ 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	170/477 (36%)
cyp-37A1	NP_496939.2	p450	41..503	CDD:278495	176/491 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830