DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	459	Identity:	160/459 - (34%)
Similarity:	252/459 - (54%)	Gaps:	54/459 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRN--YELLEPWLGKGLLTN 115
            |:|:       |||:.|       :....|..|..||..:..:.....  |..|:||||.|||.:
Mouse    89 LSWV-------GPVYPI-------LRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMS 139

  Fly   116 GGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GES-FDIYPYITLFALDAIC 178
            .|:.|...|:||||.|||.||..:.:...::..|:..:.:..|: |.| .|::.:|:|..||::.
Mouse   140 AGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSLQ 204

  Fly   179 ETAMGIKKHAQLQSDSEYVQAVQSICRVM---HKQSFSFWQRLNVFFKHTKPGKEREAALKVLHD 240
            :....:..:.| :|||:|:.|:..:..::   |:|.|.:   |::.:..|..|:....|..::|:
Mouse   205 KCIFSVDSNCQ-ESDSKYIAAILELSSLVVKRHRQPFLY---LDLLYYLTADGRRFRKACDLVHN 265

  Fly   241 ETNRVIRLRREQLIQERNEW-KPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTF 304
            .|:.||:.||..|..:..|: |.:|:      .:.|.|:|:||:.:.|.|..||:.|||.|.|||
Mouse   266 FTDAVIKERRSTLNTQGVEFLKAKAK------TKTLDFIDVLLMAEDEHGKGLSNEDIRAEADTF 324

  Fly   305 MFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLR 360
            ||.|||||:||:::.|..|:::|:.|:|..:|..| |..|:.|        .:|:|...|||:||
Mouse   325 MFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLR 389

  Fly   361 IYPSVPFFSRKVLED--LEVGKLTVPKGASISCLIYMLHRDPKNFPDPE-----RFDPDRFLVNE 418
            ::|.|...||...:|  |..|: .:|||......|:.:|.:|..:||||     ||||:    |.
Mouse   390 LHPPVLLISRCCTQDVLLPDGR-AIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPE----NP 449

  Fly   419 KQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRL 483
            ::..|.||..||||.||||||.|||.|:|.:||:.|..:|.||| |.:|:...||:.::..|:.|
Mouse   450 QKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILPD-DKEPRRKPELILRAEGGLWL 513

  Fly   484 RILP 487
            |:.|
Mouse   514 RVEP 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	154/439 (35%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	157/453 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650