DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	252/517 - (48%)	Gaps:	56/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREKHGP 65
            :.|..|:|.:|...:|.......||.:| ..:...|.|.:|.::| .:.| ...:.:...:|:|.
  Rat     9 LETWMLLATILVLLYLYGTSTHGNFKKL-GISGPKPLPFVGNILA-YRHG-FWEFDRHCHKKYGD 70

  Fly    66 VFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEP--WLGKGLLTNGGESWHRRRKL 126
            ::..:.|:..::..|||:.||.:|...  ...|..|::   .|  .|.|.:..:..|.|.|.|.|
  Rat    71 IWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF---GPAGILKKAITLSEDEEWKRLRTL 132

  Fly   127 LTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICETAMGIKKHAQL 190
            |:|.|....|.|....:.:...:||:.::.:| .|....:......:::|.|..|:.|:...:..
  Rat   133 LSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLN 197

  Fly   191 QSDSEYVQAVQSICRVMHKQSFSFWQRLNVF------FKHTKPGKEREAALKVLHDETNRVIRLR 249
            ...:.:||.|:.:.:      |:|   |:.|      |....|..| ...:.|...:..:..|..
  Rat   198 NPQNPFVQKVKKLLK------FNF---LDPFFLSVILFPFLTPVFE-AFDITVFPKDVMKFFRTS 252

  Fly   250 REQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE----LSDTDIREEVDTFMFEGHD 310
            .|::.:.|.:.|         .|:||.||.:::.:|..|..|    |:|.:|..:...|:|.|::
  Rat   253 VERMKENRMQEK---------VKQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGYE 308

  Fly   311 TTSSAIAFALSLLSKNPDVQQRAFEEA-SELEGREKES------MPYLEAVIKETLRIYPSVPFF 368
            |||||::|||.||:.:||:|::..:|. :.|..:...:      |.||:.|:.||||::|.....
  Rat   309 TTSSALSFALYLLATHPDLQKKLQDEIDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRL 373

  Fly   369 SRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAG 432
            .|...:|:|:..:.:|||..:....:.||:|||.:|:||.|.|:|| ..|:..::|:.:..|..|
  Rat   374 ERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNG 438

  Fly   433 PRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSG-----NGIRLRILPRD 489
            ||||||.:||::.:|.:|..:|:::.|...|:.| .||.  :.|.|     ..|.||.:.||
  Rat   439 PRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQ-IPLK--LRKKGFFQPEKPIILRAVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	126/456 (28%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	131/478 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810