Protein Alignment Cyp4s3 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 117/498 - (23%)
• Similarity: 203/498 - (40%)
• Gaps: 103/498 - (20%)

  Fly     3 TLALVAFVLWAAFLRYLPKILNFLRLQRFAKT-----LPGPTIGELIANVKKGEILNWLKELREK 62
            ||:||..:..||.        :.::|....|:     .|.|.:|..||..|..  :.:|:...||
Human    43 TLSLVYLIRLAAG--------HLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSP--IEFLENAYEK 97

  Fly    63 HGPVFRI-WFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYE---------LLEPWLGKGLLTN 115
            :||||.. ..||    .||      .|||::  .||..|:|.:         |..|..|||:..:
Human    98 YGPVFSFTMVGK----TFT------YLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYD 152

  Fly   116 -GGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICE 179
             ....:..::|:|..|.:   ::.||:      .:.:....||...||:.......:|  :|:.|
Human   153 VPNPVFLEQKKMLKSGLN---IAHFKQ------HVSIIEKETKEYFESWGESGEKNVF--EALSE 206

  Fly   180 TAMGIKKHA----QLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTK---PG-------KE 230
            ..:....|.    :::|.             ::::....:..|:..|.|..   ||       :.
Human   207 LIILTASHCLHGKEIRSQ-------------LNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR 258

  Fly   231 REAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDT 295
            |:.|.:.:.|...:.|:.||:.  ||:        .||:        |..||....:.|..|:|.
Human   259 RDRAHREIKDIFYKAIQKRRQS--QEK--------IDDI--------LQTLLDATYKDGRPLTDD 305

  Fly   296 DIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKESMPY--------LE 352
            ::...:...:..|..|:|:..|:....|:::..:|::.:.|...:.|.....:.|        |:
Human   306 EVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLD 370

  Fly   353 AVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLV- 416
            ..||||||:.|.:....|.......|...|:|.|..:.....:..|...::.:...|:|||:|.
Human   371 RCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD 435

  Fly   417 NEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRF 459
            |......||:..|.||...|||:.||.:::||..:.:||.|.|
Human   436 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	100/432 (23%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	102/437 (23%)