Protein Alignment Cyp4s3 and CYP24A1

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 129/507 - (25%)
• Similarity: 221/507 - (43%)
• Gaps: 104/507 - (20%)

  Fly    32 AKTLPGPT----IGELIANVKKGEIL---NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLL 89
            |..|||||    :|.|:..:.||.:.   :.|.|..:|:|.:||:..|....|....|..::.|
Human    55 AAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL- 118

  Fly    90 GNNQLLTKSRNYELLE--PWL--------GKGLLTNGGESWHR-----RRKLLTPGFHFR----- 134
                ..|:|...:.||  ||.        |.|||...||.|.|     ::||:.||...:
Human   119 ----YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKI 179

  Fly   135 --ILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDS--- 194
              :|::|...::|.|         ...|...|:|..:..::.::|| ..:..|:...||.::
Human   180 NEVLADFMGRIDELC---------DERGHVEDLYSELNKWSFESIC-LVLYEKRFGLLQKNAGDE 234

  Fly   195 --EYVQAVQSIC----RVM------HKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIR 247
              .::.|::::.    |:|      ||.       ||     ||..::...|...:.......|.
Human   235 AVNFIMAIKTMMSTFGRMMVTPVELHKS-------LN-----TKVWQDHTLAWDTIFKSVKACID 287

  Fly   248 LRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTT 312
            .|.|:..|:     |.|:                .|..:.....||..::...|........:||
Human   288 NRLEKYSQQ-----PSAD----------------FLCDIYHQNRLSKKELYAAVTELQLAAVETT 331

  Fly   313 SSAIAFALSLLSKNPDVQQRAFEEASEL-------EGREKESMPYLEAVIKETLRIYPSVPFFSR 370
            ::::.:.|..||:||.|||:..:|...:       ...:..:||||:|.:||::|:.|||||.:|
Human   332 ANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396

  Fly   371 KVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRN 435
            .:.:...:|:..:|||..:.....:|.....||.|..:|.|:|:|..:::::|||...|..|.|.
Human   397 TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRM 461

  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            |||::.|.|:|..:|..::|.|. :...|::|..:..    ||..:..|.||
Human   462 CIGRRLAELQLHLALCWIVRKYD-IQATDNEPVEMLH----SGTLVPSRELP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	113/462 (24%)
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	115/470 (24%)