Protein Alignment Cyp4s3 and CYP17A1

DIOPT Version :9

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_000093.1
• Gene: CYP17A1 / 1586
• HGNCID: 2593
• Length: 508
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 123/520 - (23%)
• Similarity: 208/520 - (40%)
• Gaps: 107/520 - (20%)

  Fly     6 LVAFVLWAAFLRYLPKILNFLRLQRFAKTLPG----------PTIGELIANVKKGEILNWLKELR 60
            |||.:|......:.||           :..||          |.:|.|....:.|.:.|...:|:
Human     4 LVALLLLTLAYLFWPK-----------RRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQ 57

  Fly    61 EKHGPVFRIWFGKDLMVMFTDPEDIKQLL--------GNNQLLT---KSRNYELLEPWLGKGL-L 113
            :|:||::.:..|....|:....:..|::|        |..|:.|   .|.|        .||: .
Human    58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN--------RKGIAF 114

  Fly   114 TNGGESW--HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA------NGESFDI-YPYI 169
            .:.|..|  |||..:.|    |.:..:..:.:|   :|:.:.:.|..      ||:|.|| :|..
Human   115 ADSGAHWQLHRRLAMAT----FALFKDGDQKLE---KIICQEISTLCDMLATHNGQSIDISFPVF 172

  Fly   170 TLF--ALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKERE 232
            ...  .:..||..........:|.....|.:.:  |..:...........|.:|     |.|..|
Human   173 VAVTNVISLICFNTSYKNGDPELNVIQNYNEGI--IDNLSKDSLVDLVPWLKIF-----PNKTLE 230

  Fly   233 ---AALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQM---EGGAE 291
               :.:|:.:|..|:::           ..:|.:...|.:     ...||.|:..:|   .|.|.
Human   231 KLKSHVKIRNDLLNKIL-----------ENYKEKFRSDSI-----TNMLDTLMQAKMNSDNGNAG 279

  Fly   292 -------LSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG------- 342
                   |||..|...:......|.:||:|.:.:.|:.|..||.|:::.:||..:..|
Human   280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTI 344

  Fly   343 REKESMPYLEAVIKETLRIYPSVP-FFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDP 406
            .::..:..|||.|:|.||:.|..| ....|...|..:|:..|.||..:...::.||.:.|.:..|
Human   345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409

  Fly   407 ERFDPDRFL--VNEKQMHP-FAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRF-LPDKDHQP 467
            ::|.|:|||  ...:.:.| .::..|.||||:|||:..|..||...:|.||:.:.. :||....|
Human   410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474

  Fly   468  467
            Human   475  474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	117/491 (24%)
CYP17A1	NP_000093.1	p450	28..493	CDD:306555	115/485 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910