DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	509	Identity:	181/509 - (35%)
Similarity:	274/509 - (53%)	Gaps:	43/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPT-------IGELIANVKKGEILNWLKEL 59
            ::|.::..:|..|...||.:......||:|    |.|.       |.||..:.:...|..|::..
Human    22 ASLLILLLLLIKAVQLYLHRQWLLKALQQF----PCPPSHWLFGHIQELQQDQELQRIQKWVETF 82

  Fly    60 RE--KHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSR-NYELLEPWLGKGLLTNGGESWH 121
            ..  .|.    :|.|| :.|...||:.:|.:||.:.  .||. :|..|.||:|.|||...|::|.
Human    83 PSACPHW----LWGGK-VRVQLYDPDYMKVILGRSD--PKSHGSYRFLAPWIGYGLLLLNGQTWF 140

  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIK 185
            :.|::|||.||:.||..:...|.::.|:::.:.......:| .:::.:::|..||.|.:.|...:
Human   141 QHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQ 205

  Fly   186 KHAQLQSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLR 249
            ...|:..:|: |:||:..:..::..:..:.:.:.:..:..|..|:....|.::.|..|::||:||
Human   206 GSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLR 270

  Fly   250 REQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSS 314
            :.||       :.|.|.:.:..||.|.|||:|||.:||.|:.|||.|:|.|||||||||||||:|
Human   271 KAQL-------QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 328

  Fly   315 AIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKV 372
            .|::.|..|:.:|..|:|..||...|.|       ...:.|||....|||.||:||.||...|::
Human   329 GISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGREL 393

  Fly   373 LEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRN 435
            ...:..  |: ::|||..:...||.||.:||.:|:||.|||.||.....| |..||..||.|.||
Human   394 STPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ-HSHAFLPFSGGSRN 456

  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGI--RLRILP 487
            |||::|||.|||.:.|:.|..:..|||....|.|:|.||.||.|||  |||.||
Human   457 CIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	159/454 (35%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	168/468 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154676
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.600