DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp4s3 and CYP3A4

DIOPT Version :10

Sequence 1:NP_573003.2 Gene:Cyp4s3 / 32444 FlyBaseID:FBgn0030615 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:465 Identity:133/465 - (28%)
Similarity:223/465 - (47%) Gaps:63/465 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LPGPTIGELIANVKKGEILNWLK-------ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN 92
            :||||....:     |.||::.|       |..:|:|.|:..:.|:..::..|||:.||.:|...
Human    38 IPGPTPLPFL-----GNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97

  Fly    93 --QLLTKSRNYELLEPWLGKGLLTNG-----GESWHRRRKLLTPGFHFRILSEFKEPMEENCRIL 150
              .:.|..|      |:...|.:.:.     .|.|.|.|.||:|.|....|.|....:.:...:|
Human    98 CYSVFTNRR------PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVL 156

  Fly   151 VRRLRTKA-NGESFDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSF 214
            ||.||.:| .|:...:......:::|.|..|:.|:...:.......:|:..:.:.|      |.|
Human   157 VRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR------FDF 215

  Fly   215 WQRLNVFFKHTKPGKEREAALKVLH------DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKR 273
               |:.||............|:||:      :.||   .||:.  ::...|.:.|..|     |.
Human   216 ---LDPFFLSITVFPFLIPILEVLNICVFPREVTN---FLRKS--VKRMKESRLEDTQ-----KH 267

  Fly   274 RLAFLDMLLLTQ----MEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAF 334
            |:.||.:::.:|    .|....|||.::..:...|:|.|::||||.::|.:..|:.:|||||:..
Human   268 RVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQ 332

  Fly   335 EEASELEGREKE-------SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCL 392
            ||...:...:..       .|.||:.|:.||||::|......|...:|:|:..:.:|||..:...
Human   333 EEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 397

  Fly   393 IYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRS 456
            .|.||||||.:.:||:|.|:|| ..|:..:.|:.:..|.:|||||||.:||::.:|.:|..:|::
Human   398 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462

  Fly   457 YRFLPDKDHQ 466
            :.|.|.|:.|
Human   463 FSFKPCKETQ 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp4s3NP_573003.2 CYP4 64..483 CDD:410721 123/429 (29%)
CYP3A4NP_059488.2 CYP3A 67..492 CDD:410743 124/431 (29%)

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