Protein Alignment Cyp4s3 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 147/533 - (27%)
• Similarity: 248/533 - (46%)
• Gaps: 87/533 - (16%)

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQR----FAKT-LPGPTIGELIANV---KKGEILNWL--KE 58
            ||:..::|.|..|     ||.:|...|    |.|. :||||....:.|.   :||   .|.  .|
Human     7 LAVETWLLLAVSL-----ILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKG---YWTFDME 63

  Fly    59 LREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNG----- 116
            ..:|:..|:.|:..:..|:..|||:.||.:|...  .:.|..|      |:...|.:.|.
Human    64 CYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRR------PFGPVGFMKNAISIAE 122

  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICET 180
            .|.|.|.|.||:|.|....|.|....:.:...:|||.||.:| .|:...:......:::|.|..|
Human   123 DEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITST 187

  Fly   181 AMGIKKHAQLQSDSEYVQAVQSICR-------VMHKQSFSF----WQRLNV-FFKHTKPGKEREA 233
            :.|:...:.......:|:..:.:.|       |:..:.|.|    .:.||: .|..
Human   188 SFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPR--------- 243

  Fly   234 ALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE----LSD 294
              ||:...|..|.:::..:|.:.:              |.|:.||.:::.:|....:|    |||
Human   244 --KVISFLTKSVKQIKEGRLKETQ--------------KHRVDFLQLMIDSQNSKDSETHKALSD 292

  Fly   295 TDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLE 352
            .::..:...|:|.|::||||.::|.:..|:.:|||||:..:|...:...:..       .:.||:
Human   293 LELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357

  Fly   353 AVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LV 416
            .|:.||||::|......|...:|:|:..:.:|||..:....|:||.|||.:.:||:|.|:|| ..
Human   358 MVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

  Fly   417 NEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPL---AELVTKS 477
            |:..:.|:.:..|.:|||||||.:||::.:|.:|..:|:::.|.|.|:.| |..|   ..|:|:
Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTE- 486

  Fly   478 GNGIRLRILPRDE 490
             ..|.|:...|||
Human   487 -KPIVLKAESRDE 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	128/471 (27%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	132/488 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810