DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	122/493 - (24%)
Similarity:	203/493 - (41%)	Gaps:	92/493 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAF----------LRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKE 58
            |.|.|..||..:          |...|..:.|            |..||.:..|.:..  .:|:.
  Rat    20 LFLAALKLWDLYCVSSRDRSCALPLPPGTMGF------------PFFGETLQMVLQRR--KFLQM 70

  Fly    59 LREKHGPVFRI-WFGK-DLMVMFTDPEDIKQ-LLGNNQLLTKSRNYELLEPW-------LGKGLL 113
            .|.|:|.:::. .||: .:.||..|  :::: |||.::|::..        |       ||.|.|
  Rat    71 KRRKYGFIYKTHLFGRPTVRVMGAD--NVRRILLGEHRLVSVH--------WPASVRTILGAGCL 125

  Fly   114 TNGGESWHR-RRKLLTPGFHFRILSEFKEPM-EENCRILVRRLRTKANGESFDIYPYITLFALDA 176
            :|..:|.|: |:|::...|:...|..:...: ||....|.:.|.....|  ..:||.:.......
  Rat   126 SNLHDSSHKQRKKVIMQAFNREALQCYVPVIAEEVSGCLEQWLSCGERG--LLVYPEVKRLMFRI 188

  Fly   177 ICETAMGIK--KHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLH 239
            .....:|.:  .....:.:.:.|:|.:.:.|.:      |...::|.|.....|.:   |..::|
  Rat   189 AMRILLGCEPGPAGGGEDEQQLVEAFEEMTRNL------FSLPIDVPFSGLYRGVK---ARNLIH 244

  Fly   240 DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTF 304
            ......||.:..:|         :|.:.|.|.|..   |.:|:....|.|..|....:::.....
  Rat   245 ARIEENIRAKIRRL---------QAAEPDAGCKDA---LQLLIEHSWERGERLDMQALKQSSTEL 297

  Fly   305 MFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE------------ASELEGREKESMPYLEAVIKE 357
            :|.||:||:||....::.|...|.|.|:..||            ..:|:....|.:.|:..||||
  Rat   298 LFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKE 362

  Fly   358 TLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMH 422
            |||:.|.||...|..|:..|:....:|||.::...|...|....:|.:.|.|:||||    ..:|
  Rat   363 TLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADSFTNKEEFNPDRF----TSLH 423

  Fly   423 P-----FAFAAFSAGPRNCIGQKFAMLELKTSLAMLLR 455
            |     |:|..|..|.|:|:|::||.:.||.....|.|
  Rat   424 PEDTSRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	114/452 (25%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	116/470 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910