DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	510	Identity:	180/510 - (35%)
Similarity:	265/510 - (51%)	Gaps:	53/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWAAFLRYLPKILNFL----RLQRFAKTL---PGP----TIGELIANVKKG---EILNWLKELRE 61
            |||:.:..:..:|..|    |.|:.|:.|   |||    ..|..:...|.|   :::.|.::...
Mouse    15 LWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPY 79

  Fly    62 KHGPVFRIWFGKDLMVM-FTDPEDIKQLLGNNQLLTKSRN-------YELLEPWLGKGLLTNGGE 118
            .|    .:|.|:.::.: ..:|:..|.:.        ||.       |:....|:|||||...|.
Mouse    80 AH----PLWLGQFIVFLNIYEPDYAKAVY--------SRGDPKAAYVYDFFLQWIGKGLLVLEGP 132

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAM 182
            .|.:.|||||||||:.:|..:.....|:.|:::.:...||: .:||||:..:...|||.:.:...
Mouse   133 KWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTF 197

  Fly   183 GIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIR 247
            |........||:.|..||..:..:|.::..||....:..:..|..|:....|.::.||.|:.|||
Mouse   198 GKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIR 262

  Fly   248 LRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTT 312
            .|:..|       :.|.||..:..:|.|.|||:||..:.|.|.:|||.|:|.|||||||||||||
Mouse   263 QRKAAL-------QDEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTT 320

  Fly   313 SSAIAFALSLLSKNPDVQQRAFEEASELEGREKES--------MPYLEAVIKETLRIYPSVPFFS 369
            :|.|::.|..::..|..|||..||..|:.| :::|        |.||...:||..|:||.||...
Mouse   321 TSGISWFLYCMALYPMHQQRCREEVREILG-DRDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVY 384

  Fly   370 RKVLEDLE-VGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAG 432
            |::.:.:. |...::|.|:.||..||.|||:...:||||.|||.||. .|....|||||..||||
Mouse   385 RQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAG 449

  Fly   433 PRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            |||||||:|||.|:|...|:.|..:.|.||....|..:.:|:.:|.|||.|.:.|
Mouse   450 PRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	165/462 (36%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	169/472 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650