DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	504	Identity:	170/504 - (33%)
Similarity:	265/504 - (52%)	Gaps:	49/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVLWA----AFLRYLPKILNFLRLQRFAKTL------PGPTI-GELIANVKKGEILNWLKELREK 62
            |..||    .||.....:..:||.|...|||      |...: |..:.:.:..:||.|:::.
Mouse    18 FFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKF--- 79

  Fly    63 HGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLL 127
            .....:...|.::.|:..||:.:|.:||.:. ...|..|:...||:|.|||...|:.|.:.|::|
Mouse    80 PSACLQCLSGSNIRVLLYDPDYVKVVLGRSD-PKASGIYQFFAPWIGYGLLLLNGKKWFQHRRML 143

  Fly   128 TPGFHFRILSEFKEPMEENCRILVRRLRTKANGES--FDIYPYITLFALDAICETAMGIKKHAQL 190
            ||.||:.||..:.:.|.::..|::.:.. |.:|:.  .:|:..::|..||.:.:.|...:...||
Mouse   144 TPAFHYDILKPYVKIMADSVNIMLDKWE-KLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQL 207

  Fly   191 QSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKH------TKPGKEREAALKVLHDETNRVIRL 248
            ..:|: |.:||:.:      .:.:|::..|.|:|:      :..|:....|.::.|:.|:.||::
Mouse   208 DENSKLYTKAVEDL------NNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHTDGVIKM 266

  Fly   249 RREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTS 313
            |:.||       :.|.|......||.|.|||:||..:||....|||.|:|.|||||||||||||:
Mouse   267 RKSQL-------QNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTA 324

  Fly   314 SAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLEAVIKETLRIYPSVPFFSRK 371
            |.|::....|:.:|:.|||..||...:.|....       .|||....|||.||:||.|...||:
Mouse   325 SGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRE 389

  Fly   372 VLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPR 434
            :...:..  |: ::|||.:.:..||.||.:|:.:|:|:.|||.|| ..:...|..|:..||.|.|
Mouse   390 LSSPVTFPDGR-SIPKGITATISIYGLHHNPRFWPNPKVFDPSRF-APDSSHHSHAYLPFSGGSR 452

  Fly   435 NCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRL 483
            ||||::|||.|||.::|:.|..:..|||....|.|:|.||.||.|||.|
Mouse   453 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	150/458 (33%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	158/468 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650