DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	508	Identity:	172/508 - (33%)
Similarity:	266/508 - (52%)	Gaps:	50/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STLALVAFVLWAAFLRYLPKILNFLRLQRFA----------KTLPGPTIGELIANVKK--GEILN 54
            |.|:|:..:...|.| ||.:.......|:|.          |.|....:.:::..:|.  .....
Mouse    23 SVLSLLLLLFKTAQL-YLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQ 86

  Fly    55 WLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSR-NYELLEPWLGKGLLTNGGE 118
            ||             | |..:.:...||:.:|.:||.:.  .|:. :|..|.||:|:|||...|:
Mouse    87 WL-------------W-GSKVRIQVYDPDYMKLILGRSD--PKAHGSYRFLAPWIGRGLLLLDGQ 135

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAM 182
            :|.:.|::|||.||:.||..:.|.|.::..:::.:.......:| .:|:.:|||..||.|.:.|.
Mouse   136 TWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAF 200

  Fly   183 GIKKHAQL-QSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVI 246
            ..:...|| :....|:|||:.:..:...:..:.:.:.::.::.:..|....:|.::.||.|::||
Mouse   201 SHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVI 265

  Fly   247 RLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDT 311
            :.||.||       :.|.|.:.:..||||.|||:||..:||.|..|||.|:|.||||||||||||
Mouse   266 KSRRSQL-------QDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDT 323

  Fly   312 TSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFS 369
            |:|.|::....|:.||:.|||..:|...|.|       .:.:.|||....|||.|||||.||..|
Mouse   324 TASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVS 388

  Fly   370 RKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAG 432
            |::...:..  |: ::|||..:....|.||.:|..:|:||.|||.||.....: |..:|..||.|
Mouse   389 RELSSPVTFPDGR-SLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSR-HSHSFLPFSGG 451

  Fly   433 PRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI 485
            .|||||::|||.|||.::|:.|..:..|||....|.|:..:|.||.|||.|.:
Mouse   452 ARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	154/447 (34%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	160/457 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650