DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	509	Identity:	136/509 - (26%)
Similarity:	244/509 - (47%)	Gaps:	101/509 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LPGPT----IGELIANVKKGEILNWLKELR--EKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN- 92
            :|||.    :|.::| .:||   .|..:::  :|:|.::.::.|:..::..|||:.||.:|...
Mouse    38 IPGPKPLPFLGTILA-YQKG---FWECDIQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKEC 98

  Fly    93 -QLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPGF-------HFRILSEFKEPMEENCRI 149
             ...|..|.:..: ..|.|.:..:..|.|.|.|.||:|.|       .|.|:::|.:       :
Mouse    99 YSTFTNRRRFGPV-GILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTD-------V 155

  Fly   150 LVRRLRT-KANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICR-------V 206
            |||.:|. ...|:...:......:::|.|..|:.|:...:.......:|:.::.:.:       .
Mouse   156 LVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLF 220

  Fly   207 MHKQSFSF----WQRLNV---------FFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERN 258
            :....|.|    :..|||         ||                   |..|.|::..::.::.
Mouse   221 LSVTLFPFLTPVFDALNVSLFPRDVISFF-------------------TTSVERMKENRMKEKE- 265

  Fly   259 EWKPEAEQDDVGAKRRLAFLDMLLLTQ----MEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFA 319
                         |:|:.||.:::.:|    .|....|||.:|..:...|:|.|::|||||::||
Mouse   266 -------------KQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTSSALSFA 317

  Fly   320 LSLLSKNPDVQQRAFEEA-SELEGREKES------MPYLEAVIKETLRIYPSVPFFSRKVLEDLE 377
            |.||:.:||||::..:|. :.|..:...:      |.||:.|:.||||:||......|....|:|
Mouse   318 LYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVE 382

  Fly   378 VGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKF 441
            :..|.:|||..:....:.||:|||.:|:||.|.|:|| ..|:..::|:.:..|.:|||||||.:|
Mouse   383 INGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSGPRNCIGMRF 447

  Fly   442 AMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSG-----NGIRLRILPRDE 490
            |::.:|.:|..:|:::...|.|:.: .||.  ::|.|     |.:.|:::.|||
Mouse   448 ALINMKVALVRVLQNFTVQPCKETE-IPLK--LSKQGLLQPENPLLLKVVSRDE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	127/481 (26%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	132/499 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810