DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	522	Identity:	141/522 - (27%)
Similarity:	257/522 - (49%)	Gaps:	60/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFL----RYLPKILNFLRLQRFAKT-LPGPTIGELIANVKKGEILNWLK--- 57
            :|.|:|..:||.|..|    ||..:     :.:.|.|. :|||.....:     |.:||:.|
Mouse     4 VSALSLETWVLLAISLVLLYRYGTR-----KHELFKKQGIPGPKPLPFL-----GTVLNYYKGLW 58

  Fly    58 ----ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNG 116
                |..:|:|..:.::.|:..::..||||.||.:|...  .:.|..|::..: ..:.|.:..:.
Mouse    59 KFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPV-GIMSKAISISK 122

  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICET 180
            .:.|.|.|.||:|.|....|.|....:|:...|||:.||.|| .|:...:...:..:::|.|..|
Mouse   123 DDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITST 187

  Fly   181 AMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRL---NVFFKHTKPGKEREAALKVLHDET 242
            :.|:...:....:..:|:..:.:.|      |.|:..|   .|.|....|..|   .|.:.....
Mouse   188 SFGVNVDSLNNPEDPFVEKAKKLLR------FDFFDPLLFSVVLFPFLTPVYE---MLNICMFPK 243

  Fly   243 NRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE-----LSDTDIREEVD 302
            :.:...::  .:....|.:.:::|     |.|:.||.:::.:......:     |||.:|..:..
Mouse   244 DSIEFFKK--FVDRMKESRLDSKQ-----KHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSI 301

  Fly   303 TFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKES------MPYLEAVIKETLR 360
            .|:|.|::||||.::|.|..|:.:||:|::..:|..| |..:...:      |.||:.|:.||||
Mouse   302 IFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLR 366

  Fly   361 IYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPF 424
            :||......|...:|:|:..:.:|||:::....|.||.||:::.:||.|.|:|| ..|:..:.|:
Mouse   367 LYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPY 431

  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPLA-ELVTKSGNGIRLRILP 487
            .:..|..|||||:|.:||::.:|.:|..:::::.|.|.|:.| |..|: :.:.:....|.|:::|
Mouse   432 VYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVP 496

  Fly   488 RD 489
            ||
Mouse   497 RD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	124/460 (27%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	127/476 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810