DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP001861

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_321208.5	Gene:	AgaP_AGAP001861 / 1281265	VectorBaseID:	AGAP001861	Length:	505	Species:	Anopheles gambiae

Alignment Length:	511	Identity:	189/511 - (36%)
Similarity:	297/511 - (58%)	Gaps:	31/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLK---------EL 59
            :.|.|.::.......:..::...:||:..|..|||....::.|:.:   ..||.         ||
Mosquito     1 MILQALLIAGVVYLLISHLIERKKLQKINKHFPGPKPLPVVGNLLQ---FAWLDIPGVFEKVVEL 62

  Fly    60 REKHGPVFRIW--FGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHR 122
            .:.||..:.:|  |...:::| |..::::::|...| ..|:..|:.:|||||.|||...||.|.:
Mosquito    63 HQTHGQDYMMWSLFNWTILMM-TSRKNVEKVLLAKQ-TEKALLYQFIEPWLGTGLLIASGEKWFQ 125

  Fly   123 RRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKH 187
            |||::||.|||:||.:|..........:|:.||....|:.||||.|:||.|||:||||:||....
Mosquito   126 RRKIITPTFHFKILEQFVRVFNTETDTMVQLLRKHVGGKEFDIYDYVTLMALDSICETSMGTTVD 190

  Fly   188 AQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGK-EREAALKVLHDETNRVIRLRRE 251
            ||...|::|||.|:.:..::..::.|........:....|.. |:...:|.||..|:.|||.|||
Mosquito   191 AQHNPDNQYVQNVKRMAVLVLLRTISIVGPYPTLYNLFHPNAWEQRRVIKQLHAFTDNVIRSRRE 255

  Fly   252 QLIQERNEWKP-EAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSA 315
            ||.:|:.:... :..::::.:||:|.|||:||...:| |..||:.|||||||||||||||||:|.
Mosquito   256 QLAKEKAQNVAFDLNEENLYSKRKLTFLDLLLNVTVE-GKPLSNLDIREEVDTFMFEGHDTTTSG 319

  Fly   316 IAFALSLLSKNPDVQQRAFEE----------ASELEGREKESMPYLEAVIKETLRIYPSVPFFSR 370
            |:|.:..|::|||||:|.:||          .:||..:..:...||:.|:||.||:||.|....|
Mosquito   320 ISFTIYELARNPDVQERVYEEIVSILGKDHKTAELTYQNLQEFKYLDLVVKEGLRMYPPVGIIGR 384

  Fly   371 KVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVN-EKQMHPFAFAAFSAGPR 434
            .::||||:...|||.|.::...||::||:|:.:|:|.:|||.||..: |.:..||.:..||.|.|
Mosquito   385 ALVEDLELNGTTVPAGQNVLVPIYVIHRNPEIYPNPNQFDPSRFAEDAESKRGPFDYLPFSIGAR 449

  Fly   435 NCIGQKFAMLELKTSLAMLLRSYRFLPDKD-HQPKPLAELVTKSGNGIRLRILPRD 489
            |||||::|::|:|.:|..|:.:||.||.:. .:.:...:||.:...||.::|:.|:
Mosquito   450 NCIGQRYALMEMKVTLIKLIANYRILPGESLGKLRVKTDLVLRPDIGIPVKIVLRE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	178/458 (39%)
AgaP_AGAP001861	XP_321208.5	p450	33..493	CDD:278495	180/465 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	6	5.830