DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP009246

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_320022.4	Gene:	AgaP_AGAP009246 / 1280199	VectorBaseID:	AGAP009246	Length:	516	Species:	Anopheles gambiae

Alignment Length:	518	Identity:	200/518 - (38%)
Similarity:	305/518 - (58%)	Gaps:	38/518 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTL--ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANV------KKGEILNWLK 57
            :||:  .::.||::|.:|::|.|   ..:|.:..:.:|||....:|..:      ::.||...|.
Mosquito     5 LSTIFHGVLVFVVFAIYLQWLMK---RWQLSQIFEKIPGPKAYPIIGTMYSFIGKQRHEIFYLLD 66

  Fly    58 ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHR 122
            |...::..:.|:|.|....|..:.||.::|::|:::.:.|:..|..|..|||.||||:.||.||:
Mosquito    67 ERTRRYPEIHRVWTGLTPEVRISKPEYVEQVIGSSKHIEKATMYRFLHDWLGNGLLTSKGERWHQ 131

  Fly   123 RRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAMGIKK 186
            .|||:||.|||.||..|.:...||...:|..||..|: |:..::||:|...|||.|||||||:|.
Mosquito   132 HRKLITPTFHFNILDGFCDVFAENSEEMVEYLRPHADTGKPVNVYPFIAKAALDIICETAMGVKV 196

  Fly   187 HAQLQ-SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRR 250
            :||.: .:::||:||..:.|:..::....|..|:..:..::.....:.||..:|:.:..|||.|:
Mosquito   197 NAQSEGEENDYVKAVCELSRLFVERMVRPWLHLDFIWLRSRFAARYKNALDTVHNYSREVIRDRK 261

  Fly   251 EQLIQERNEWKPEAEQDD---VGAKRRLAFLDMLLLTQMEGGAE---LSDTDIREEVDTFMFEGH 309
            ..|  |..:....||..|   .|.:.|:||||:||    ||...   ::|.|:||||||||||||
Mosquito   262 AAL--ESAKKSAGAETSDGEAFGVRMRMAFLDLLL----EGNQAHNIMTDEDVREEVDTFMFEGH 320

  Fly   310 DTTSSAIAFALSLLSKNPDVQQRAFEEASEL--EGREK-------ESMPYLEAVIKETLRIYPSV 365
            |||::.|::.|.||:.:||||:|..||...:  .|.::       ..:..||..|||.||:||||
Mosquito   321 DTTTAGISWVLFLLALHPDVQERVCEEIESIFPPGDDRPATMQDLNELKLLERCIKEALRLYPSV 385

  Fly   366 PFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAF 429
            .||.|.:.||:::|...||....:....|.:|||.:.:||||:||||||| .|.:..||:|:..|
Mosquito   386 SFFGRTLSEDVQLGGHQVPAQTIVGIHAYHVHRDERFYPDPEKFDPDRFLPENTENRHPYAYIPF 450

  Fly   430 SAGPRNCIGQKFAMLELKTSLAMLLRSYRF--LPDKDHQPKPLAELVTKSGNGIRLRILPRDE 490
            |||||||||||||:||.|:.::.:||.||.  :..:|.| |.:.||:|:..:||.|.:..|.:
Mosquito   451 SAGPRNCIGQKFALLEEKSIVSSVLRRYRLRSVRTRDEQ-KIMHELITRPKDGILLYLESRQK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	183/459 (40%)
AgaP_AGAP009246	XP_320022.4	p450	39..505	CDD:278495	189/472 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	7	6.930