DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP009240

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_320018.4	Gene:	AgaP_AGAP009240 / 1280195	VectorBaseID:	AGAP009240	Length:	519	Species:	Anopheles gambiae

Alignment Length:	523	Identity:	206/523 - (39%)
Similarity:	300/523 - (57%)	Gaps:	39/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFL----RLQRFAKTLPGP-------TIGELIANVKKGEILN 54
            ||:.:.|..:|....|..|..:|.:|    ::.:....:|||       |:..|......|:|.:
Mosquito     1 MSSYSTVDMLLVVLVLLLLTPVLQWLIRRVQMSQIYDKIPGPKAYPFVGTLYLLFGKKSHGKIFS 65

  Fly    55 WLK-ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGE 118
            ..: .:..::..:.|||.|....|..:..|.::|::|.::...|:..|..|..|||:||||:.||
Mosquito    66 HTRARVTRQYDGIHRIWVGMTPEVRLSRAEYVEQIIGASKHTEKATLYRFLGDWLGEGLLTSKGE 130

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAM 182
            .|.:.|||:||.|||.||..|.|...||..:||.||:..|| |:..:||||:|..|||.||||||
Mosquito   131 RWFQHRKLITPTFHFNILDGFCEVFAENGAVLVERLQRHANTGQPVNIYPYVTKAALDVICETAM 195

  Fly   183 GIKKHAQLQ-SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVI 246
            |::.|||.. .|:.||.||..:..:..::....|......|:.:..|:.:...|.:||..|.:||
Mosquito   196 GVQVHAQTAGEDNAYVNAVYELSSLFLERLVRPWLHPEWTFRRSALGRRQAQLLAILHGYTRKVI 260

  Fly   247 RLRREQLIQ----ERNEWKPEAEQDDVGAKRRLAFLDMLL--LTQMEGGAELSDTDIREEVDTFM 305
            :.||..|.|    |||:  ||||.|.:|.::||||||:||  .|...|...|:|.|:||||||||
Mosquito   261 QERRRTLDQQHAGERNQ--PEAEGDGLGRRKRLAFLDLLLQSATTGTGSPLLTDEDVREEVDTFM 323

  Fly   306 FEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG--------REKESMPYLEAVIKETLRIY 362
            |||||||::.:::||.||:.:|:||:|..:|...:.|        ::..:|..||..:|||||:|
Mosquito   324 FEGHDTTTAGMSWALFLLALHPEVQERVHQEIDSIFGGSDRPATMQDLTAMRLLERCLKETLRLY 388

  Fly   363 PSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNE--KQMHPFA 425
            |||.||.|...:|:.:|...||.|..:....|.:|||.:.|||.|.|||||||...  :..||:|
Mosquito   389 PSVAFFGRTTSKDVTLGGYHVPAGTIVGIHAYNVHRDERFFPDAETFDPDRFLPERTAENRHPYA 453

  Fly   426 FAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKP----LAELVTKSGNGIRLRIL 486
            :..||||||||||||||:||.|..::.:||.:|.   :.|:.:.    :.||:|:..:||.|.:.
Mosquito   454 YIPFSAGPRNCIGQKFALLEEKCLVSSILRRFRI---RSHRTRAEQLIVNELITRPKDGILLYLE 515

  Fly   487 PRD 489
            .|:
Mosquito   516 ERE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	191/459 (42%)
AgaP_AGAP009240	XP_320018.4	p450	40..512	CDD:278495	196/476 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	7	6.930