DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP6Z2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_317252.1	Gene:	CYP6Z2 / 1277759	VectorBaseID:	AGAP008218	Length:	492	Species:	Anopheles gambiae

Alignment Length:	505	Identity:	119/505 - (23%)
Similarity:	205/505 - (40%)	Gaps:	96/505 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREKHGPVF 67
            ||||||.|::.. |||:     :...:|..  ||     .|...:..|.| ..:.|.:|..|...
Mosquito     5 TLALVAAVIFLV-LRYI-----YSHWERHG--LP-----HLKPEIPYGNI-RTVAEKKESFGTAI 55

  Fly    68 RIWFGKDL------------MVMFTDPEDIKQLLGNNQLLTKSRNY--------ELLEPWLGKGL 112
            ...:.|..            .::..||...|:::.|:     .:|:        |..:|: ...|
Mosquito    56 NNLYHKSSDRLLGIYLFFRPAILIRDPHLAKRIMVND-----FQNFHDRGVYCNEEHDPF-SANL 114

  Fly   113 LTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESF-DIYPYITLFALDA 176
            ....|:.|...|..|||.|....|......:.:....|:.|:...|:.::. |:....:.|.||.
Mosquito   115 FALPGQRWKNLRAKLTPTFTSGQLRNMLPTLLDVGNKLIDRMNKVADEKAIVDMRDIASRFVLDT 179

  Fly   177 ICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSF-SFWQRLNVF-----FKHTKPGKEREAAL 235
            |.....|.:.:....|:..::..::   |....::| ..::...||     .|.|:....:...:
Mosquito   180 IASVFFGFEANCIHNSEDPFLSTLR---RANRGRNFIDNFRSSGVFICPGLLKLTRMTSLQPELI 241

  Fly   236 KVL---------HDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE 291
            |.:         |.|.|::   .|:..:|...:.:.||::                      |:|
Mosquito   242 KFVMEIITHQIDHREKNQI---TRKDFVQLLIDLRREADK----------------------GSE 281

  Fly   292 LSDTDIREEVDTFMF--EGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREK--------E 346
            .:.|..:...:.|:|  .|.:|:::.|:|.|..||.||:...:..:|..|:..|..        :
Mosquito   282 EALTIEQCAANVFLFYIAGAETSTATISFTLHELSHNPEAMAKLQQEIDEMMERYNGEITYENIK 346

  Fly   347 SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERF 409
            .|.||:..:|||||.||.:|..:|:...|.:|  ..:.:.||..:...:..:..:.|.|||||.:
Mosquito   347 EMKYLDLCVKETLRKYPGLPILNRECTIDYKVPDSDVVIRKGTQVIIPLLSISMNEKYFPDPELY 411

  Fly   410 DPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRF 459
            .|:||....|.....|:..|.||||||||.:..:|..|..|..||..::|
Mosquito   412 SPERFDEATKNYDADAYYPFGAGPRNCIGLRQGVLVSKIGLVFLLSKFKF 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	108/473 (23%)
CYP6Z2	XP_317252.1	p450	59..462	CDD:278495	100/437 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910