DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP006047

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_316096.4	Gene:	AgaP_AGAP006047 / 1276718	VectorBaseID:	AGAP006047	Length:	505	Species:	Anopheles gambiae

Alignment Length:	517	Identity:	198/517 - (38%)
Similarity:	275/517 - (53%)	Gaps:	59/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQ-----RFAKTLPGPTIGELIAN--------------VKK 49
            |.||||:|          ||..||:|     |..|..|||....|:.|              :.:
Mosquito     8 LLLVAFLL----------ILYELRVQLSTHYRAGKRFPGPRALPLLGNAHNLLFNDQRRTFQLPR 62

  Fly    50 GEILNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLT 114
            |    |    ...:|..:||.....|.:.....:|::.||.:.:|:.||..|.||..:||.|||.
Mosquito    63 G----W----AATYGDTYRILVRGILNLNAFQAKDVEPLLSSPKLIEKSMIYSLLHRFLGIGLLN 119

  Fly   115 NGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAIC 178
            :.|..|..||::|||.|||.||..|....:|.||.||.::...|: |....:.|..|.|.|:.||
Mosquito   120 STGSKWQHRRRILTPAFHFNILPSFLLTFQEECRRLVAQIGQYADKGAPVALQPLATKFTLNTIC 184

  Fly   179 ETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETN 243
            |||||||..:...: :||...:::|..::.::..:.|...:..:|.:......|..|:.:|..|.
Mosquito   185 ETAMGIKLDSMTMA-NEYRSKIEAIGTMLLQRLMNPWLFEDFTYKLSGLQGRFEKLLQPVHAFTR 248

  Fly   244 RVIRLRREQLIQE-RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFE 307
            .:|:.|||...|. ||......|......|:|.|.||.||..  |...::.:..||||||||.||
Mosquito   249 SIIQQRRELFHQNVRNIGDFSEENIYTNLKQRYAMLDTLLAA--EAKEQIDEDGIREEVDTFTFE 311

  Fly   308 GHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL-----------EGREKESMPYLEAVIKETLRI 361
            ||||||:|:.|.|.||:.:||||||.:||..|:           ..|:...:.|::.|:||:||:
Mosquito   312 GHDTTSAAVIFTLLLLAHSPDVQQRLYEELQEVAQSRTDADDEFTQRDYTELRYMDMVLKESLRL 376

  Fly   362 YPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL---VNEKQMHP 423
            ||.|||.||.:.||...|...|||....:..|:.|||||..|||||||||||||   |.|:.  |
Mosquito   377 YPPVPFISRNISEDTMFGDRLVPKDTLFNVHIFDLHRDPAVFPDPERFDPDRFLPECVAERS--P 439

  Fly   424 FAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP-DKDHQPKPLAELVTKSGNGIRLR 484
            :|:..|||||||||||:||:|||||.||.:|..:|.|| .|..:...:|:|:.::.:.|.:|
Mosquito   440 YAYVPFSAGPRNCIGQRFAILELKTVLAAILMHFRILPVTKREELVFVADLILRTKDPIMVR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	181/464 (39%)
AgaP_AGAP006047	XP_316096.4	p450	35..502	CDD:278495	185/480 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	5	4.930