DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP005992

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_316034.4	Gene:	AgaP_AGAP005992 / 1276664	VectorBaseID:	AGAP005992	Length:	517	Species:	Anopheles gambiae

Alignment Length:	526	Identity:	126/526 - (23%)
Similarity:	204/526 - (38%)	Gaps:	114/526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LPGPT----IGEL------IANVKKGEILNWLKELREKHGPVFRIWF--GKDLMVMFTDPEDIKQ 87
            :|||.    :|.|      |......|:....::...::|.:.|...  |:|::.:: ||:|:..
Mosquito    32 IPGPRGPLGLGNLYQYIPGIGRYSFDELHRSGEDKYRQYGSIVRETMVPGQDIVWLY-DPDDVAT 95

  Fly    88 LLGNNQ--LLTKSRNYELLEP--------WLGKGLL-TNGGESWHRRRKLLTPGFHFRILSEFKE 141
            :|.:..  :....|::..||.        :...||| |||.|.|..|.:|.......:.:..|..
Mosquito    96 VLDDRTPGMYPSRRSHTALEKYRKDRPNVYRTAGLLPTNGAEWWKIRSELQKGLSSPQNVRNFLP 160

  Fly   142 PMEENCRILVRRLRTKAN-GESF---DIYPYITLFALDAICETAMGIK--KHAQLQSD-----SE 195
            ..::..:..|.|||.:.. |:|.   |..|.::...|:.||..|..::  ..::.|.|     |.
Mosquito   161 ATDKITKEFVTRLRAQMEPGKSILIEDFMPLVSRLNLELICLLAFDVRLDSFSEEQMDPGSLSSR 225

  Fly   196 YVQAVQSI--CRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQER- 257
            .:::.::.  |.:...|.|..|:    :|                  ||....|||:.|...|:
Mosquito   226 LMESAETTNSCILPTDQGFQLWR----YF------------------ETPAYRRLRKAQEFMEKT 268

  Fly   258 ------------NEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHD 310
                        ||.:......:.|:|.        |:.:......|...||.......:..|..
Mosquito   269 AVELVSQKLLYFNEDQQRLASGEHGSKS--------LMEEYLRNPNLELNDIIGMASDLLLAGVH 325

  Fly   311 TTSSAIAFALSLLS-KNPDVQQRAFEEASEL--EGREK--------ESMPYLEAVIKETLRIYPS 364
            |||...||||..|. .....|.|.:.||.::  :.||.        ....|..||:|||||:.|.
Mosquito   326 TTSYTTAFALYHLGLHGATAQDRLYREAKKILPDPRENRIGAAVLGSEASYCRAVLKETLRLNPI 390

  Fly   365 VPFFSRKVLEDLEVGKLTVPKGA------SISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQ-MH 422
            .....|.:..|..:|...||:|.      .|||      |....|.||:.|.|:|::...|: :|
Mosquito   391 SIGVGRILNRDHVLGGYQVPRGTVIVTQNMISC------RQEAYFRDPQLFLPERWMRETKEPVH 449

  Fly   423 PFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRF-----LPDKDHQPKPLAELVTKSGNGIR 482
            |.....|..|.|:||.::.|...:...|..|:||:..     :| .|.:.|    |:.:....||
Mosquito   450 PHLVLPFGHGMRSCIARRLAEQSMLVLLLRLIRSFEIEWAGTVP-MDVKTK----LINQPDQPIR 509

  Fly   483 LRILPR 488
            ||:..|
Mosquito   510 LRMKAR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	119/505 (24%)
AgaP_AGAP005992	XP_316034.4	p450	33..487	CDD:299894	117/490 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910