Protein Alignment Cyp4s3 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 181/516 - (35%)
• Similarity: 276/516 - (53%)
• Gaps: 42/516 - (8%)

  Fly     1 MSTLAL-VAFVLWAAFLRYLPKILNFLRLQRFAKTLPGP-----TIGELIANVKKGEILNWLKEL 59
            :|||.| :.|.|:...||:|....:|....|..:..|.|     .:|.|...:.....|...|::
Human    24 VSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKV 88

  Fly    60 REKHGPVFRIWFGKDL-MVMFTDPEDIKQLLGNNQLLTKSRN--YELLEPWLGKGLLTNGGESWH 121
            .:....|..:|.|..| :::...|:.||.|||.:..:....:  |..|:||||.|||.:.|:.|.
Human    89 LDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWS 153

  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGE--SFDIYPYITLFALDAICETAMGI 184
            |.|:||||.|||.||..:.:...::..|:..:.|..|.|.  |.|::.:|:|..||::.:.....
Human   154 RHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSY 218

  Fly   185 KKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLR 249
            ..:.| :..|:|:.|:..:..:..::.:.....|:..:..:..|:....|..::|..|..||:.|
Human   219 NSNCQ-EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQER 282

  Fly   250 REQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSS 314
            |..|.|:..|...:|:|.     :.|.|:|:|||.:.|.|.||||.|||.|.|||||||||||||
Human   283 RRALRQQGAEAWLKAKQG-----KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSS 342

  Fly   315 AIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLRIYPSVPFFSR 370
            .|::.|..|:|.|:.|::..||..| ::|||.|        .:|:....|||:||.||.|...||
Human   343 GISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSR 407

  Fly   371 KVLEDLEV--GKLTVPKGASISCL--IYMLHRDPKNFPD-----PERFDPDRFLVNEKQMHPFAF 426
            :..||:::  |:: :|||  |.||  ||..|.:|..:||     |.|||||    |.:|..|.|:
Human   408 QCTEDIKLPDGRI-IPKG--IICLVSIYGTHHNPTVWPDSKVYNPYRFDPD----NPQQRSPLAY 465

  Fly   427 AAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            ..|||||||||||.|||.||:..:|:.|..:|...|:..:.:...||:.::.||:.|::.|
Human   466 VPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	162/441 (37%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	164/453 (36%)