Protein Alignment Cyp4s3 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 135/494 - (27%)
• Similarity: 222/494 - (44%)
• Gaps: 70/494 - (14%)

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGP-----TIGELIANVKKGEI-------- 52
            :.:..|:||.|...|:.         |.:...:.:|||     .:|.|....||.|:
Human     8 LGSAVLLAFGLCCTFVH---------RARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDV 63

  Fly    53 -LNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNG 116
             |:|.|    |:|||.|:.......|:.|.||.:|:.|.:.:....|:.|..|:...|:.|...|
Human    64 FLDWAK----KYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124

  Fly   117 ------GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFAL 174
                  .|.||::|:::...|....|....|...|....||..|..||:|:: ..:...:|..|:
Human   125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM 189

  Fly   175 DAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLH 239
            |.:.:.|.|::....|.:.....|||    ::|.:...:....|..|.    |||.::  |:.:.
Human   190 DILAKAAFGMETSMLLGAQKPLSQAV----KLMLEGITASRNTLAKFL----PGKRKQ--LREVR 244

  Fly   240 DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQM---EGGAELSDTDIREEV 301
             |:.|.:|......:|.|.|.....|  :|.|.         :|||:   |.||: .|..:.:..
Human   245 -ESIRFLRQVGRDWVQRRREALKRGE--EVPAD---------ILTQILKAEEGAQ-DDEGLLDNF 296

  Fly   302 DTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREK-------ESMPYLEAVIKETL 359
            .||...||:|:::.:||.:..||:.|::..|...|..|:.|.::       ..:.||..|:||:|
Human   297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESL 361

  Fly   360 RIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPF 424
            |:||......|.:.|:..:..:.||....:....|::.|....|.||..|:||||.....:.. |
Human   362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-F 425

  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLR--SYRFLP 461
            .:..||.|.|:||||:||.:|:|..:|.||:  .:|.:|
Human   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	117/417 (28%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	121/432 (28%)