DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and runx1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_012813452.1	Gene:	runx1 / 100485449	XenbaseID:	XB-GENE-483164	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	245	Identity:	48/245 - (19%)
Similarity:	78/245 - (31%)	Gaps:	84/245 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RFAKTLP--------GPTIGELIANVKKGEILNWLKELREKHGP-------------VFRIWFGK 73
            |..||||        |......:..|..|...|:..|||.....             |.|...||
Frog    80 RCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGK 144

  Fly    74 DL---MVMFTDPEDIKQLLGNNQLLTKSRNYEL------------LEPWLGKGLLTNGGESWHRR 123
            ..   :.:||:|.         |:.|..|..::            .:|.:|.||:  ||:.....
Frog   145 SFTLTITVFTNPP---------QVATYHRAIKITVDGPREPRRPKYDPIIGPGLV--GGQIQAEI 198

  Fly   124 RKLLTPG--FHFRILSEF---KEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMG 183
            ..:.:.|  .....:..|   ::.::|         :||:...||.    ..|..|:.:..|||.
Frog   199 YSIYSLGKSADSSCVGSFTGHRQKLDE---------QTKSGTLSFS----ERLSELEHLRRTAMR 250

  Fly   184 IKKH-------------------AQLQSDSEYVQAVQSICRVMHKQSFSF 214
            :..|                   .|.||..:..:.||:.....:.||:.:
Frog   251 VSPHHPTPTPNPRATLNHSTAFNPQPQSQIQDTRQVQASPPWSYDQSYQY 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	45/240 (19%)
runx1	XP_012813452.1	Runt	58..178	CDD:279225	22/106 (21%)
runx1	XP_012813452.1	RunxI	407..500	CDD:285676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900