DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	207/515 - (40%)	Gaps:	100/515 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VAFVLWAAFLRYLPKILNFLRLQRFAK--TLPGPTIGELIAN---VKKGEILNWLKELREKHGPV 66
            |..||..:|:     :|..|..||.|:  ..||||...:|.|   :...:|...|....:.:|||
Mouse     5 VVLVLCLSFM-----LLLSLWRQRSARRNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPV 64

  Fly    67 FRIWFGKDLMVMFTDPEDIKQ-LLGNNQLLTKSRNYELLEP-WLGKGLLTNGGESWHRRRKLLTP 129
            |.::||...:|:....|.||: |:.:.::.:...::...:. ..|||:..:.|..|...|.....
Mouse    65 FTLYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKGKGIGFSHGNVWKATRVFTVN 129

  Fly   130 GFHFRILSEFKEPME----ENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQL 190
              ..|.|:..|..:|    |..:.|::.|: |.||...|....|.....:.||..   :.::...
Mouse   130 --TLRNLAMGKRTIENKVQEEAQWLMKELK-KTNGSPCDPQFIIGCAPCNVICSI---VFQNRFD 188

  Fly   191 QSDSEYVQAVQSI-----------CRVMHKQSFSFWQ---RLNVFFK-HT-------KPGKEREA 233
            ..|.:::..:..:           |::.:........   |.|.||| ||       :..||.|.
Mouse   189 YKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRHNKFFKNHTWIKSYLLEKIKEHEE 253

  Fly   234 ALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLL-TQMEGGAELSDTDI 297
            :|    |.||                     .:|         |:|..|: .:.:.|.|..:..|
Mouse   254 SL----DVTN---------------------PRD---------FIDYFLIQRRQDKGIEHMEYTI 284

  Fly   298 RE---EVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGR-------EKESMPYLE 352
            ..   .|...:|.|.:|.||.:.|||.||.|:..:..:..||...:.||       :::.|||..
Mouse   285 EHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRKHMPYTN 349

  Fly   353 AVIKETLRIYPSVP-FFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL- 415
            |::.|..|.....| ....:|..|.:.....:|||..:...:..:..|...||:||.|||..||
Mouse   350 AMVHEVQRYVDLGPTSLVHEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLD 414

  Fly   416 --VNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP-----DKDHQPK 468
              .|.|:..  .|..||||.|.|:|:..|.:||...|..:|::::..|     |.|..||
Mouse   415 DNGNFKKSD--YFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDTTPK 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	120/485 (25%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	120/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010