DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	513	Identity:	180/513 - (35%)
Similarity:	277/513 - (53%)	Gaps:	50/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFL--------RLQRFAKTLPGPTIGELIANVK-KGEILNWL 56
            :|....||.||  ..|..|.|.:.|.        .||:|    |.|.......:.: |||
Mouse    15 LSGFLQVASVL--GLLLLLVKAVQFYLHRKWLLKALQQF----PSPPFHWFFGHEQFKGE----- 68

  Fly    57 KELRE-----KHGP-VFRIWF-GKDLMVMFTDPEDIKQLLGNNQLLTKSRN-YELLEPWLGKGLL 113
            :||:|     :|.| .|..|| |.:..:...||:.:|.:||.:.  .|:.. |.||.||:|.|||
Mouse    69 QELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRSD--PKANGIYRLLAPWIGYGLL 131

  Fly   114 TNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRL-RTKANGESFDIYPYITLFALDAI 177
            ...|:.|.:.|::|||.||:.||..:.:.|.::.|:::.:. |......|.:|:.:|:|..||.:
Mouse   132 LLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLDTV 196

  Fly   178 CETAMGIKKHAQLQSD-SEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDE 241
            .:.|...|...|:..: ..|:||:..:..:.|.:..:.:.:.:..::.:..|:..:.|.::.||.
Mouse   197 MKCAFSHKGSVQVDGNYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDH 261

  Fly   242 TNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMF 306
            |:.||::|::||       :.|.|.:::..||||.|||:||..:||.|..:||.|:|.|||||||
Mouse   262 TDGVIKMRKDQL-------QDEGELENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMF 319

  Fly   307 EGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPS 364
            ||||||:|.:::....|:.:|:.|||..||...|.|       ...:.:||....|||.||:||.
Mouse   320 EGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPP 384

  Fly   365 VPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFA 427
            ||...|::...:..  |: ::|||..::..||.||.:||.:|:||.|||.|| ..:...|..:|.
Mouse   385 VPGIVRELSTSVTFPDGR-SLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRF-APDSPRHSHSFL 447

  Fly   428 AFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI 485
            .||.|.|||||::|||.|||..:|:.|..:..|||....|:|||.:|.||.|||.|.:
Mouse   448 PFSGGARNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	158/453 (35%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	167/466 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.600