DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp24a1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001082927.1	Gene:	cyp24a1 / 100004700	ZFINID:	ZDB-GENE-060825-1	Length:	505	Species:	Danio rerio

Alignment Length:	546	Identity:	130/546 - (23%)
Similarity:	222/546 - (40%)	Gaps:	121/546 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AFLRYLPKILNFLR-----LQRFAKT-----------------------LPGPT----IGELIAN 46
            |.|:..|:||..|:     ||....|                       :||||    .|.||..
Zfish     3 AHLQRAPQILELLKKKTVGLQHCKPTSSVCVLDSKDAAGSAPCAHSLDSIPGPTNWPLFGSLIEV 67

  Fly    47 VKKGEIL---NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNY-ELLE-- 105
            ::.|.:.   ..|....:|.|.:||:..|....|....|    .||  ..|..|..:| |.||
Zfish    68 IRNGGLKRQHETLIHFHKKFGKIFRMKLGSFESVHIGSP----CLL--EALYRKEGSYPERLEIK 126

  Fly   106 PWL--------GKGLLTNGGESWHR-----RRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTK 157
            ||.        ..|||...|..|.|     ::||:.|....::..:..|...:    |::|: .|
Zfish   127 PWKAYRDMRDEAYGLLILEGRDWQRVRSAFQQKLMKPTEVMKLDGKINEVAAD----LIKRI-GK 186

  Fly   158 ANGESFDIYPYITLFALDAIC----ETAMGIKKHAQLQSDSEYVQAVQSICRV----------MH 208
            .||:...:|..:..::.:.||    :...|:.:.:..:...:::.||:::...          :|
Zfish   187 VNGKMDALYFELNKWSFETICYVIYDKRFGLLQDSVSKEGMDFITAVKTMMSTFGTMMVTPVELH 251

  Fly   209 KQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKR 273
            |       .||     ||..|:        |.|....|....:..|.:..:.:...|.||
Zfish   252 K-------TLN-----TKTWKD--------HTEAWDRIFSTAKHYIDKNLQKQSNGEADD----- 291

  Fly   274 RLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEAS 338
                    .|:.:.....|:..::..........|.:||::::.:.:..||:||..|.:..:|..
Zfish   292 --------FLSDIFHNGNLTKKELYAATTELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKEIQ 348

  Fly   339 EL-------EGREKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYML 396
            ::       .....:|||||:|.:||::|:.|||||.||.:.:|..:|..|:|||..:......:
Zfish   349 DVVPAGQTPRAEHIKSMPYLKACLKESMRVSPSVPFTSRTLDKDTVLGDYTLPKGTVLMLNSQAI 413

  Fly   397 HRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP 461
            ....:.|.:..:|.|:|:|..:..::|||...|..|.|.|||::.|.|:::..|..:||.|:.:.
Zfish   414 GVSEEYFDNGRQFRPERWLEEKSSINPFAHVPFGVGKRMCIGRRLAELQIQLGLCWILRDYKIVA 478

  Fly   462 DKDHQPKPLAELVTKSGNGIRLRILP 487
            .   ..:|:..|  .||..:..|.||
Zfish   479 T---DLEPVDSL--HSGTLVPSRELP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	114/477 (24%)
cyp24a1	NP_001082927.1	p450	53..493	CDD:278495	118/488 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910