DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rab3-GEF and Madd

DIOPT Version :9

Sequence 1:NP_001259560.1 Gene:Rab3-GEF / 32442 FlyBaseID:FBgn0030613 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_030106062.1 Gene:Madd / 228355 MGIID:2444672 Length:1647 Species:Mus musculus


Alignment Length:1940 Identity:757/1940 - (39%)
Similarity:998/1940 - (51%) Gaps:453/1940 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QQKASLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQ 68
            |:|  .||||:||:.||||.  .|....:       .|.|:||||||..||.:||||.|:|:|||
Mouse     3 QKK--FCPRLLDYLVIVGAR--HPSSDSV-------AQTPELLRRYPLEDHPEFPLPPDVVFFCQ 56

  Fly    69 PEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER--PSSAAGSAGAGNDRP 131
            ||||.||..||  .::||.|||||.|||||:|.|||||||||||..::  |...           
Mouse    57 PEGCLSVRQRR--MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEK----------- 108

  Fly   132 GNGGPGGHGGGAGGGAGGGGRGGRRSSAFRRESWRKSMERSSDSAFSSDYRSNVAPSDSDRELTS 196
                       ..||||..|:.|..:|....|:          :|.||:..|.:.|         
Mouse   109 -----------VEGGAGPRGKEGAHTSGASEEA----------AAGSSESGSTLQP--------- 143

  Fly   197 RRDSDQQRLHSHHSHHQPHHPSASPAVPKLGLMAPSADSESGGSHSP-SPRASRKRTKLRNQSLT 260
                                              |||||....:.|| ..|.::..::.||.:||
Mouse   144 ----------------------------------PSADSTPDVNQSPRGKRRAKAGSRSRNSTLT 174

  Fly   261 SLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGH-VSDATPSIV 324
            |||::||:|||:||||||:.||:|:|.|:|....|::|..:.:.||.:|.:.||. :.:...|.:
Mouse   175 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 239

  Fly   325 LHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLG 389
            |.|:||||.||.|||.:||||.|..||::|||...:.:.|.|||||.:||:||||||||||||||
Mouse   240 LQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLG 304

  Fly   390 VETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAP 454
            |:.||:|.|.|:.|:||:.||||||||||||||||.|:||||||||||||||||::.||||||||
Mouse   305 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAP 369

  Fly   455 TPFVIGVPASFLVYKKNFRLPDDIWVVDLDSTKLTPPTGGYEEIPPLPEPEGTILKNHLKQAMLL 519
            ||::|||||||.:||.:|::|||:|:|||||.::..||.. |.:|.|||||...||.||||    
Mouse   370 TPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNA-EVLPILPEPESLELKKHLKQ---- 429

  Fly   520 MDEAGLGALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQ 584
                   ||.||:.....:.:   |....:..:.|.|||                   |.|...|
Mouse   430 -------ALASMSLNTQPILN---LEKFHEGQEIPLLLG-------------------RPSNDLQ 465

  Fly   585 GTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVA 649
            .|.|:.         .||.:||.||||||||||||||||||:.|.|..|..|||||||:||||||
Mouse   466 STPSTE---------FNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVA 521

  Fly   650 FQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHAL 714
            ||..|||.||||.:.|..:.|||||||:..||.|.|:|.||.|:.....||..:||||||:||.|
Mouse   522 FQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQL 586

  Fly   715 TPIRFSVWDDGSSLNGALR--SLKQLECQPTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSP 777
            .||.:.|:|..|.|..||.  ..:..:..||::|||||:..|.||||||||.||||||...|::.
Mouse   587 QPIHYRVYDGNSQLAEALSVPPERDSDSDPTEDSGSDSQDYDDSSSSYSSLGDFVSEMMKCDING 651

  Fly   778 SLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYPEGIADAVASKEEEDEERADS------- 835
                     :.|:|.|.|.::..|.:            |...|.:..::|.:|...||       
Mouse   652 ---------DTPNVDPLTHAALGDAS------------EVEIDELQPQKEGEEPGPDSENSQENP 695

  Fly   836 PVSSSSSRSDLSSPSFNRDSEFDFQPKGGQTLGSTTVGSGAAAPSFELATPLAMRLEATIKMASI 900
            |:.||||.:..||||....|..      .:...||.:|..|.|   .::.||     ..:..:..
Mouse   696 PLRSSSSTTASSSPSTVVHSAH------SEAADSTEMGDKATA---GISKPL-----PPVPPSIC 746

  Fly   901 EQESDTVSTATGKTIAAGSKLQRHPSDSESRPEKKIPP---------PLTPPVKQPGVSNI---- 952
            :...|...|.||:    ||..||...:....|:...||         ..||...| .||..    
Mouse   747 KSTVDRRQTETGE----GSVCQRTYDNPYFEPQYGFPPEEDEEEQGESYTPRFSQ-HVSGSRAQK 806

  Fly   953 LARTGS----SGSSSSSPGRQSSQSSLFEN--------FASHAKELVRETTRQSSQEGLLAHVDK 1005
            |.|..|    |.|.:.|..|.||.:|...|        ..|.|..|.|.            |...
Mouse   807 LLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRN------------HSTS 859

  Fly  1006 FTLHAKKAAGEASKQALEVSKQAAGVSKNTLEDLTYVGKSTLGDLTKTAKEAATKKGIIKIEEHS 1070
            |:|                       |..||.             ||.|:|..|           
Mouse   860 FSL-----------------------SNLTLP-------------TKGAREKTT----------- 877

  Fly  1071 AGGAGPPPKSPGSQLATHKQVQQSGGQGGGNNFFSAIGTDFNGLASSTSTMFSGMFGKKSQQKQV 1135
                 |.|......|.|..::....|.|.|..                                 
Mouse   878 -----PFPSLKVFGLNTLMEIVTEAGPGSGEG--------------------------------- 904

  Fly  1136 PVQQKQPNVSAGKAKSGINFDPFPGRKGLV-ERTPLIKHSGPRQTQEELTRQQNQERSHSNAENQ 1199
                                    .|:.|| :::.:|||| |...:|.   ...|.||.:::|||
Mouse   905 ------------------------NRRALVDQKSSVIKHS-PTVKREP---SSPQGRSSNSSENQ 941

  Fly  1200 TFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKK-IAPDDHIDDVCVTKPV 1263
            .|||:|.:.||.|:|||||.:.:.::|:|.|..|..||||||:.:..: .|..|.|.||.:::.|
Mouse   942 QFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEISRKV 1006

  Fly  1264 WKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKEINEGSDMSSSLLSSHAASPM 1328
            :||||..::.....|:.::|:.|||||||:|.|:|:|.|||:|||    .|......:.:..:|:
Mouse  1007 YKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKE----PDKRKRSPTENVNTPV 1067

  Fly  1329 GSRENL-------------------RSPSSPNGSHSALGSE-------------WASPQESRKSS 1361
            |....|                   |:||:.......|.:.             |...||.:|..
Mouse  1068 GKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFVASVELWNKHQEVKKQK 1132

  Fly  1362 TQLAHGGPGG--------------SHSGAPINRRLSSA------DSQDGQSTTEMFKDMLSQKRS 1406
            . |....|.|              |...|.....|:||      ||..|.|...|.:   |..:.
Mouse  1133 A-LEKQRPEGIKPVFDLGETEEKKSQMSADSGVSLTSASQRTDQDSVIGVSPAVMIR---SSSQD 1193

  Fly  1407 ALKNMLTSFDSDTTTSKDSKKS-----------SGNLWSGKSTLSAGFRYTG---------GHLI 1451
            :..:.:.|..|..|...||..|           |.:|.|.::|||.....|.         .|.:
Mouse  1194 SEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSAIFGKAHSL 1258

  Fly  1452 NTSSSP-------SPD-SPRVYLFEGLLGKD---------------------RLNLWNQMQFWED 1487
            .....|       |.| |.||||:|||||:|                     |..||:|||||||
Mouse  1259 KPKEKPAGSPIRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWED 1323

  Fly  1488 AFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDE 1552
            ||||||..||:.:||||||.||::||.||.|.:|||||.||||||:|:|:||.:.::::.|.|::
Mouse  1324 AFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKND 1388

  Fly  1553 IRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLR 1617
            ||:|:|||:|||||||||||:|:.|:||:|:|||.|:.::..|||.:.:|:|.||.|||.||.:.
Mouse  1389 IRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIF 1453

  Fly  1618 FMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNC 1682
            ||||.||.:||||..||:.||||||:|:||||.||||:||||||||.:|||:|:||:||:|||.|
Mouse  1454 FMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYC 1518

  Fly  1683 IKEAMERGGTPTNV----PELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNS---KFFVRLDHIR 1740
            :|::|||.......    ||||||||||||.|||||||||.|||:.|.|.::   |.|:.|:||:
Mouse  1519 VKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQERKVFIELNHIK 1583

  Fly  1741 KCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQICYSVLCVFSYVAAGQDQKKN 1795
            ||.|.: |:|||||:.|:.:.::..||::.|:.:|||||||:||||||.:..:::
Mouse  1584 KCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEED 1637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rab3-GEFNP_001259560.1 uDENN 10..111 CDD:214824 59/100 (59%)
DENN 260..486 CDD:214823 142/226 (63%)
dDENN 613..681 CDD:129037 46/67 (69%)
MaddXP_030106062.1 uDENN 7..97 CDD:214824 59/100 (59%)
VCX_VCY <101..>150 CDD:373664 19/123 (15%)
DENN 172..401 CDD:214823 143/228 (63%)
dDENN 485..553 CDD:129037 46/67 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850160
Domainoid 1 1.000 692 1.000 Domainoid score I133
eggNOG 1 0.900 - - E1_KOG3570
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H14249
Inparanoid 1 1.050 1139 1.000 Inparanoid score I216
Isobase 1 0.950 - 0 Normalized mean entropy S6066
OMA 1 1.010 - - QHG48534
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006143
OrthoInspector 1 1.000 - - oto93643
orthoMCL 1 0.900 - - OOG6_106194
Panther 1 1.100 - - LDO PTHR13008
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4941
SonicParanoid 1 1.000 - - X4435
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.830

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