DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5599 and LAT1

DIOPT Version :9

Sequence 1:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_014328.3	Gene:	LAT1 / 855653	SGDID:	S000005015	Length:	482	Species:	Saccharomyces cerevisiae

Alignment Length:	490	Identity:	133/490 - (27%)
Similarity:	225/490 - (45%)	Gaps:	65/490 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISQRAALRRCLHVT----SSLDKTVSFNLSDIGEGIREVTVKEWFVKEGDTVEQFDNLCEVQSDK 79
            ||:.:.|.|.|.:.    :|..:.....:..:...:.:..:..|..||||.:...:.:.|:::||
Yeast    11 ISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDK 75

  Fly    80 ASVTITSRYDGKITKI--HHKIDEIALVGKPLLDFDVVNEDEDEP-------EDS-SSSSSSTSS 134
            |.:....:.||.:.||  .....:|. |.||:..:  |.:..|.|       ||| |.|.:||.:
Yeast    76 AQMDFEFQEDGYLAKILVPEGTKDIP-VNKPIAVY--VEDKADVPAFKDFKLEDSGSDSKTSTKA 137

  Fly   135 DSSASENEEKQSAEASATPT-------------EGRVIIPATPSVRRLAKEHQLDLAKVPATGKN 186
            ..:..:.|:||.|.|..|.|             :||:.  |:|..:.:|.|..:.|..|..||..
Yeast   138 QPAEPQAEKKQEAPAEETKTSAPEAKKSDVAAPQGRIF--ASPLAKTIALEKGISLKDVHGTGPR 200

  Fly   187 GRVLKGDILEFLGQVPPGTNVPHPTLLAKTPSAAPSGAASVSVPADR---------VEVLKGVRK 242
            ||:.|.||..:|.:....::..... .|.||:||.|...:.|.|:..         :..::.:..
Yeast   201 GRITKADIESYLEKSSKQSSQTSGA-AAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIG 264

  Fly   243 AMLKSMTESLKIPHFAYSDEIDMTQLMQFRNQLQLVAKENGVPKLTFMPFCIKAASIALSKYPIV 307
            ..|...|:.  ||.:..|.:|.:::|::.|..|...|  |...||:.....:||.::|..:.|..
Yeast   265 ERLLQSTQG--IPSYIVSSKISISKLLKLRQSLNATA--NDKYKLSINDLLVKAITVAAKRVPDA 325

  Fly   308 NSSLDLASESLV--FKGAHNISVAIDTPQGLVVPNIKNCQTKTIIEIAKDLNALVERGRTGSLSP 370
            |:.. |.:|:::  ||.. ::|||:.||.||:.|.:|||:.|.:.:|:.::..||:|.|...|:|
Yeast   326 NAYW-LPNENVIRKFKNV-DVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAP 388

  Fly   371 ADFADGTFSLSNIGVIGGTYTHPCIMAPQ----VAIGAMGR-----TKAVPRFNDKDEVVKAYVM 426
            .:|..||..:||:|:.........|:.|.    :||..:.|     ..|...|:..::|
Yeast   389 EEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQV------ 447

  Fly   427 SVSWSADHRVIDGVTMASFSNVWKQYLENPALFLL 461
            :::.:.|||.|||...|.|....|..:|||...||
Yeast   448 TITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	16/71 (23%)
		PLN02528	41..462	CDD:215289	127/464 (27%)
		E3_binding	161..194	CDD:280908	11/32 (34%)
		2-oxoacid_dh	248..461	CDD:278621	66/223 (30%)
LAT1	NP_014328.3	PDHac_trf_mito	36..482	CDD:273567	125/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810