Protein Alignment CG5599 and PDHX

DIOPT Version :9

• Sequence 1: NP_573000.1
• Gene: CG5599 / 32441
• FlyBaseID: FBgn0030612
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_003468.2
• Gene: PDHX / 8050
• HGNCID: 21350
• Length: 501
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 139/489 - (28%)
• Similarity: 219/489 - (44%)
• Gaps: 57/489 - (11%)

  Fly     6 LRNGATCWLLRNCISQRAALRRCLHVTSSL-DKTVSFNLSDIGEGIREVTVKEWFVKEGDTVEQF 69
            |..||..|.:     .|.|..|..|.|..| ...:...:..:...:.|..:.:|..|||:.|...
Human    28 LVKGALGWSV-----SRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAG 87

  Fly    70 DNLCEVQSDKASVTITSRYDGKITKI-----HHKIDEIALVGKPLLDFDVVNEDED-----EPED 124
            |.|||:::|||.||:.:..||.:.||     ...|...:|:|.      :|.|.||     .|:|
Human    88 DALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGL------IVEEGEDWKHVEIPKD 146

  Fly   125 SSSSSSSTSSDSSASENEEKQSAEASATPTEGRVIIPATPSVRRLAKEHQLDLAKVPATGKNGRV 189
            .......:.........|.:.|.........|.:....:|:.|.:.::|.||.::..|||..|..
Human   147 VGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIF 211

  Fly   190 LKGDILEFL-----GQVPPGTNVPHPTLLAKTPS-----AAPSGAASVSVPADR----------V 234
            .|.|.|:.:     |::......|.||.....||     |.||....|..|...          .
Human   212 TKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFT 276

  Fly   235 EV-LKGVRKAMLKSMTESLK-IPHFAYSDEIDMTQLMQFRNQLQLVAKENGVPKLTFMPFCIKAA 297
            |: ...:|:.:.|.:|||.. :||...:.:.|:..:::.|..|   .|::  .|::...|.||||
Human   277 EIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDL---VKDD--IKVSVNDFIIKAA 336

  Fly   298 SIALSKYPIVNSSLD-LASESLVFKGAHNISVAIDTPQGLVVPNIKNCQTKTIIEIAKDLNALVE 361
            ::.|.:.|.||.|.| ...:.|.|   .:||||:.|.:||:.|.||:...|.|.|||..:.||.:
Human   337 AVTLKQMPDVNVSWDGEGPKQLPF---IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSK 398

  Fly   362 RGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAIGAMGRTKAVPRFNDKDE----VVK 422
            :.|.|.|.|.::..|:||:||:|:.|.......|..||..|.|:||.:.|.:..:.:|    :.:
Human   399 KARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQ 463

  Fly   423 AYVMSVSWSADHRVIDGVTMASFSNVWKQYLENP 456
            ..:::|:.|:|.||:|......|...:|..||||
Human   464 RQLITVTMSSDSRVVDDELATRFLKSFKANLENP 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	22/74 (30%)
		PLN02528	41..462	CDD:215289	129/453 (28%)
		E3_binding	161..194	CDD:280908	10/32 (31%)
		2-oxoacid_dh	248..461	CDD:278621	72/215 (33%)
PDHX	NP_003468.2	PDHac_trf_mito	58..500	CDD:273567	129/454 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..175		4/32 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..268		11/42 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810