DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5599 and Pdhx

DIOPT Version :9

Sequence 1:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_780303.1	Gene:	Pdhx / 27402	MGIID:	1351627	Length:	501	Species:	Mus musculus

Alignment Length:	493	Identity:	135/493 - (27%)
Similarity:	228/493 - (46%)	Gaps:	65/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LRNGATCWLLRNCISQRAALRRCLHVTSSLD-KTVSFNLSDIGEGIREVTVKEWFVKEGDTVEQF 69
            |..||..|.:     .|.|..|..|.|..|. ..:...:..:...:.:..:.:|..|||:.|...
Mouse    28 LAQGAAAWPV-----DRGASWRWFHSTQLLQADPIKVLMPSLSPTMEQGNIVKWLRKEGEAVSAG 87

  Fly    70 DNLCEVQSDKASVTITSRYDGKITKIHHKIDE----------IALVGKPLLDFDVVNEDED---- 120
            |:|||:::|||.||:.:..||.:.||  .::|          |||         :|.|.||
Mouse    88 DSLCEIETDKAVVTLDANDDGILAKI--VVEEGAKNIQLGSLIAL---------MVEEGEDWKQV 141

  Fly   121 -EPEDSSSSSSSTSSDSSASENEEKQSAEASATPTEGRVIIPATPSVRRLAKEHQLDLAKVPATG 184
             .|:|.|:....:...:....:.:.|....:....:|......:|:.|.:.::|.||.::..|||
Mouse   142 EIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARNILEKHSLDASQGTATG 206

  Fly   185 KNGRVLKGDILEF-----LGQVPPG--TNVPHPTLLAKTPSAAPSGAA-------SVSVPADR-- 233
            ..|...|.|.|:.     :|::...  .:.|.|:|.|..|..|.:|.:       .||:|...
Mouse   207 PRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQATAGPSYPRPMTPPVSIPGQPNA 271

  Fly   234 ----VEV-LKGVRKAMLKSMTESLK-IPHFAYSDEIDMTQLMQFRNQLQLVAKENGVPKLTFMPF 292
                .|: ...:|:.:.|.:|||.. :||...:.:.|:..:::.|..|   .|::  .|::...|
Mouse   272 AGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDL---VKDD--IKVSVNDF 331

  Fly   293 CIKAASIALSKYPIVNSSLDLASESLVFKGAHNISVAIDTPQGLVVPNIKNCQTKTIIEIAKDLN 357
            .|:||::.|.:.|.||.:.|  .|......:.:||||:.|.:||:.|.||:...|.|.|||..:.
Mouse   332 IIRAAAVTLKQMPGVNVTWD--GEGPKQLPSVDISVAVATDKGLITPIIKDAAAKGIQEIADSVK 394

  Fly   358 ALVERGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAIGAMGRTKAVPRFNDKDE--- 419
            .|.::.|.|.|.|.::..|:||:||:|:.|.......|..||..|.|:||.:.|.:..:.:|
Mouse   395 VLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKLTEDEEGNP 459

  Fly   420 -VVKAYVMSVSWSADHRVIDGVTMASFSNVWKQYLENP 456
             :.:..:::|:.|:|.||:|......|...:|..||||
Mouse   460 QLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	22/79 (28%)
		PLN02528	41..462	CDD:215289	125/457 (27%)
		E3_binding	161..194	CDD:280908	10/32 (31%)
		2-oxoacid_dh	248..461	CDD:278621	68/214 (32%)
Pdhx	NP_780303.1	lipoyl_domain	57..131	CDD:133458	22/84 (26%)
		PDHac_trf_mito	58..500	CDD:273567	125/458 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..176		3/30 (10%)
		E3_binding	183..215	CDD:280908	10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..256		7/27 (26%)
		2-oxoacid_dh	291..500	CDD:278621	68/214 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810