DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5599 and Dlat

DIOPT Version :9

Sequence 1:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_663589.3	Gene:	Dlat / 235339	MGIID:	2385311	Length:	642	Species:	Mus musculus

Alignment Length:	448	Identity:	136/448 - (30%)
Similarity:	219/448 - (48%)	Gaps:	78/448 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TVKEWFVKEGDTVEQFDNLCEVQSDKASVTITSRYDGKITKIHHKIDEIALV---------GKPL 109
            ||:.|..|.|:.:.:.|.|.|:::|||::....:.:|.:.||        ||         |.||
Mouse   233 TVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKI--------LVPEGTRDVPLGAPL 289

  Fly   110 LDFDVVNEDED-------EPEDSSSSSSSTSSD-----SSASENEEKQSAEASATPT--EGRVII 160
            .  .:|.:.||       .|.:.:|.....:..     ::.....:..:...||.|.  :|||.:
Mouse   290 C--IIVEKQEDIAAFADYRPTEVTSLKPQAAPPAPPPVAAVPPTPQPVAPTPSAAPAGPKGRVFV 352

  Fly   161 PATPSVRRLAKEHQLDLAKVPATGKNGRVLKGDILEFLGQVPPGTNVPHPTLLAKTPS-AAPSGA 224
              :|..::||.|..:||.:|..||..||::|.||..|:                  || |||:.|
Mouse   353 --SPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFV------------------PSKAAPAAA 397

  Fly   225 ASVSVPADRVE----------VLKGVRKAMLKSMTESLK-IPHFAYSDEIDMTQLMQFRNQLQLV 278
            |:::.|..||.          .:..:|:.:.:.:.:|.: |||:..|.:::|.:::..|.:|..:
Mouse   398 AAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKM 462

  Fly   279 AKENGVPKLTFMPFCIKAASIALSKYPIVNSS-LDLASESLVFKGAH--NISVAIDTPQGLVVPN 340
            .:..|  |::...|.|||:::|..|.|..||| :|     .|.:..|  ::|||:.||.||:.|.
Mouse   463 LEGKG--KISVNDFIIKASALACLKVPEANSSWMD-----TVIRQNHVVDVSVAVSTPAGLITPI 520

  Fly   341 IKNCQTKTIIEIAKDLNALVERGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAIGAM 405
            :.|...|.:..||.|:.:|..:.|.|.|.|.:|..|||::||:|:.|.......|..||..|.|:
Mouse   521 VFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAI 585

  Fly   406 GRT--KAVPRFNDKDEVVKAYVMSVSWSADHRVIDGVTMASFSNVWKQYLENPALFLL 461
            |.:  |.:|..|:|...| |.||||:.|.||||:||...|.:...:|:|||.|...||
Mouse   586 GASEDKLIPADNEKGFDV-ASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	17/63 (27%)
		PLN02528	41..462	CDD:215289	136/448 (30%)
		E3_binding	161..194	CDD:280908	12/32 (38%)
		2-oxoacid_dh	248..461	CDD:278621	78/218 (36%)
Dlat	NP_663589.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..99
		lipoyl_domain	91..164	CDD:133458
		lipoyl_domain	218..292	CDD:133458	19/68 (28%)
		PDHac_trf_mito	220..642	CDD:273567	134/446 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..346		3/32 (9%)
		E3_binding	351..384	CDD:280908	12/34 (35%)
		2-oxoacid_dh	431..642	CDD:278621	78/218 (36%)
		Catalytic. /evidence=ECO:0000250	466..642		70/183 (38%)
		CoA-binding. /evidence=ECO:0000250	610..621		6/10 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810