DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5599 and DBT

DIOPT Version :9

Sequence 1:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001909.4	Gene:	DBT / 1629	HGNCID:	2698	Length:	482	Species:	Homo sapiens

Alignment Length:	484	Identity:	230/484 - (47%)
Similarity:	311/484 - (64%)	Gaps:	60/484 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLLRNGATCWL---------LRNCISQRAALRRCLHVTSSLDKTVSFNLSDIGEGIREVTVKEWF 59
            |:|:....|:.         ..:.:...||||         .:.|.|.||||||||||||||||:
Human    30 HVLKPNYVCFFGYPSFKYSHPHHFLKTTAALR---------GQVVQFKLSDIGEGIREVTVKEWY 85

  Fly    60 VKEGDTVEQFDNLCEVQSDKASVTITSRYDGKITKIHHKIDEIALVGKPLLDFDVVNEDEDEPED 124
            |||||||.|||::||||||||||||||||||.|.|:::.:|:||.|||||:|.:  .|...:.|:
Human    86 VKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIE--TEALKDSEE 148

  Fly   125 SSSSSSSTSSDSSASENEEKQSAEASATPTEGRVIIPATPSVRRLAKEHQLDLAKVPATGKNGRV 189
            ....:.:.|.|            |.:....:||..: |||:|||||.|:.:.|::|..:||:||:
Human   149 DVVETPAVSHD------------EHTHQEIKGRKTL-ATPAVRRLAMENNIKLSEVVGSGKDGRI 200

  Fly   190 LKGDILEFLGQ-----VPPGTNV--------PH----PTLLAKTPSAAPSGAASVSVPADRVEVL 237
            ||.|||.:|.:     :||...|        |.    |.|::|.|         |....|:.|.:
Human   201 LKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPP---------VFTGKDKTEPI 256

  Fly   238 KGVRKAMLKSMTESLKIPHFAYSDEIDMTQLMQFRNQLQLVAKENGVPKLTFMPFCIKAASIALS 302
            ||.:|||:|:|:.:||||||.|.||||:|:|::.|.:|:.:|...|: ||:||||.:||||:.|.
Human   257 KGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGI-KLSFMPFFLKAASLGLL 320

  Fly   303 KYPIVNSSLDLASESLVFKGAHNISVAIDTPQGLVVPNIKNCQTKTIIEIAKDLNALVERGRTGS 367
            ::||:|:|:|...:::.:|.:|||.:|:||.|||:|||:||.|..:|.:||.:||.|.:.|....
Human   321 QFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQ 385

  Fly   368 LSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAIGAMGRTKAVPRFNDKDEVVKAYVMSVSWSA 432
            ||..|...|||:|||||.||||:..|.||.|:|||||:|..||:||||.|.||.||.:|:|||||
Human   386 LSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSA 450

  Fly   433 DHRVIDGVTMASFSNVWKQYLENPALFLL 461
            |||||||.||:.|||:||.||||||..||
Human   451 DHRVIDGATMSRFSNLWKSYLENPAFMLL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	54/69 (78%)
		PLN02528	41..462	CDD:215289	222/438 (51%)
		E3_binding	161..194	CDD:280908	17/32 (53%)
		2-oxoacid_dh	248..461	CDD:278621	119/212 (56%)
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	222/438 (51%)
DBT	NP_001909.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..168		4/32 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160096
Domainoid	1	1.000	269	1.000	Domainoid score	I1862
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1819
Isobase	1	0.950	-	0	Normalized mean entropy	S1721
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D428202at33208
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto91252
orthoMCL	1	0.900	-	-		OOG6_101891
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3954
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750