DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5599 and Dbt

DIOPT Version :9

Sequence 1:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_034152.2	Gene:	Dbt / 13171	MGIID:	105386	Length:	482	Species:	Mus musculus

Alignment Length:	454	Identity:	223/454 - (49%)
Similarity:	300/454 - (66%)	Gaps:	43/454 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RRCLHVTSSLD-KTVSFNLSDIGEGIREVTVKEWFVKEGDTVEQFDNLCEVQSDKASVTITSRYD 89
            |..|...:.|. :.|.|.||||||||||||:|||:|||||||.|||::|||||||||||||||||
Mouse    51 RHSLRTAAVLQGQVVQFKLSDIGEGIREVTIKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYD 115

  Fly    90 GKITKIHHKIDEIALVGKPLLDFDVVNEDEDEPEDSSSSSSSTSSDSSASENEEKQSAEASATPT 154
            |.|.::::.:|:||.|||||:|.:.         ::...|.....::.|..::|....|.....|
Mouse   116 GVIKRLYYNLDDIAYVGKPLIDIET---------EALKDSEEDVVETPAVSHDEHTHQEIKGQKT 171

  Fly   155 EGRVIIPATPSVRRLAKEHQLDLAKVPATGKNGRVLKGDILEFLGQ-----VPPG-----TNVP- 208
                  .|||:|||||.|:.:.|::|..:||:||:||.|||.||.:     :||.     |..|
Mouse   172 ------LATPAVRRLAMENNIKLSEVVGSGKDGRILKEDILSFLEKQTGAILPPSPKSEITPPPP 230

  Fly   209 ------HPTLLAKTPSAAPSGAASVSVPADRVEVLKGVRKAMLKSMTESLKIPHFAYSDEIDMTQ 267
                  .||.:||.|         |....||.|.:.|.:|||:|:|:.:||||||.|.||||:||
Mouse   231 QPKDRTFPTPIAKPP---------VFTGKDRTEPVTGFQKAMVKTMSAALKIPHFGYCDEIDLTQ 286

  Fly   268 LMQFRNQLQLVAKENGVPKLTFMPFCIKAASIALSKYPIVNSSLDLASESLVFKGAHNISVAIDT 332
            |::.|.:|:.||...|: ||:||||.:||||:.|.::||:|:|:|...:::.:|.:|||.:|:||
Mouse   287 LVKLREELKPVALARGI-KLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDT 350

  Fly   333 PQGLVVPNIKNCQTKTIIEIAKDLNALVERGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMA 397
            ..||:|||:||.|.:::.|||.:||.|.:.|.:|.|...|...|||:|||||.|||||..|.|:.
Mouse   351 ELGLIVPNVKNVQVRSVFEIAMELNRLQKLGSSGQLGTTDLTGGTFTLSNIGSIGGTYAKPVILP 415

  Fly   398 PQVAIGAMGRTKAVPRFNDKDEVVKAYVMSVSWSADHRVIDGVTMASFSNVWKQYLENPALFLL 461
            |:|||||:|..||:|||:.|.:|.||.:|:||||||||||||.||:.|||:||.||||||..||
Mouse   416 PEVAIGALGAIKALPRFDQKGDVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	52/69 (75%)
		PLN02528	41..462	CDD:215289	219/438 (50%)
		E3_binding	161..194	CDD:280908	17/32 (53%)
		2-oxoacid_dh	248..461	CDD:278621	118/212 (56%)
Dbt	NP_034152.2	E3_binding	172..205	CDD:280908	17/32 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..252		10/43 (23%)
		2-oxoacid_dh	267..479	CDD:278621	118/212 (56%)
		lipoyl_domain	65..138	CDD:133458	54/72 (75%)
		PLN02528	67..482	CDD:215289	219/438 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850465
Domainoid	1	1.000	265	1.000	Domainoid score	I1892
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0	Normalized mean entropy	S1721
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D428202at33208
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto94833
orthoMCL	1	0.900	-	-		OOG6_101891
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3954
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750