DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lsd-2 and PLIN5

DIOPT Version :9

Sequence 1:	NP_572996.1	Gene:	Lsd-2 / 32437	FlyBaseID:	FBgn0030608	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001013728.2	Gene:	PLIN5 / 440503	HGNCID:	33196	Length:	463	Species:	Homo sapiens

Alignment Length:	263	Identity:	60/263 - (22%)
Similarity:	102/263 - (38%)	Gaps:	63/263 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LERIIKLPVVNAAWDKSQDVYGKVKGKNRVFEWALTAAEDCV----TRAVTTAAPFVTKLDRPIA 100
            ::|::.||:|.|......|||...|.::.:...|...||:||    |||:..|.|.:..|...:|
Human    23 VQRVVALPLVRATCTAVCDVYSAAKDRHPLLGSACRLAENCVCGLTTRALDHAQPLLEHLQPQLA 87

  Fly   101 YVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQPHLERVVKFKAAGQQKAASLKDLAW 165
            .::....:|:||||.|.|.::...:.:...||    |||...:..||.....|::.:..||
Human    88 TMNSLACRGLDKLEEKLPFLQQPSETVVTSAK----DVVASSVTGVVDLARRGRRWSVELK---- 144

  Fly   166 QKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVE--------------EDNDDKQNA 216
                        ....:.||.....:|.|::::.|..|.::.              ||...:|..
Human   145 ------------RSVSHAVDVVLEKSEELVDHFLPMTEEELAALAAEAEGPEVGSVEDQRRQQGY 197

  Fly   217 VVQNGKSSENDMPVPASEDPVLHTVQTVGRLSNKISRRVYRNVSRQIKQVQKGNINDYLSSLIAA 281
            .|:                        :|.||.:|....|.:...:::| .|....|.|:.|...
Human   198 FVR------------------------LGSLSARIRHLAYEHSVGKLRQ-SKHRAQDTLAQLQET 237

  Fly   282 LKL 284
            |:|
Human   238 LEL 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lsd-2	NP_572996.1	Perilipin	40..>287	CDD:281086	60/263 (23%)
PLIN5	NP_001013728.2	Essential for lipid droplet targeting. /evidence=ECO:0000250	1..173		44/169 (26%)
		Interaction with LIPE. /evidence=ECO:0000250	1..108		28/84 (33%)
		Perilipin	16..368	CDD:281086	60/263 (23%)
		Interaction with PNPLA2 and ABHD5. /evidence=ECO:0000250	185..463		16/81 (20%)
		Recruits mitochondria at the lipid droplet surface. /evidence=ECO:0000250	444..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437332at2759
OrthoFinder	1	1.000	-	-		FOG0001967
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950