Protein Alignment dob and PNPLA3

DIOPT Version :10

• Sequence 1: NP_572995.1
• Gene: dob / 32436
• FlyBaseID: FBgn0030607
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_079501.2
• Gene: PNPLA3 / 80339
• HGNCID: 18590
• Length: 481
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 120/282 - (42%)
• Similarity: 168/282 - (59%)
• Gaps: 14/282 - (4%)

  Fly     8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLLLE--RIAGASAGALAACCLICDLPLECMAGDFLRVV 70
            ||||:||||||.||||...||.:|||.||.:  .:.|||||||....::..:|||........:|
Human     9 SLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLV 73

  Fly    71 QEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQEL 135
            ::.:..::|.|.|.|||.:.|.:|:...||.:.|.|.||::.||||||||..||::|:|.|:.|:
Human    74 RKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEV 138

  Fly   136 LQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPLLD-EHTVTVSPFCGESDICPRDQNPHLL 199
            :.||:||||||..|||:||..|||||:||..|||:|.:| :.|:|||||.||.||||:.::.:.|
Human   139 VDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFL 203

  Fly   200 QLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLNE---GFKIQE 261
            .::|  ....:||...||..:.|..||.....:...|.:||.|..:||....:.|.   |.|...
Human   204 HVDI--TKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSS 266

  Fly   262 KG------MISWIHQQMEREKE 277
            :|      |.||.:..::...|
Human   267 EGMDPEVAMPSWANMSLDSSPE 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	112/247 (45%)
PNPLA3	NP_079501.2	Pat_PNPLA3	8..259	CDD:132860	113/251 (45%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	14..19		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	45..49		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	166..168		1/1 (100%)