DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dob and pnpla2

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001072695.1	Gene:	pnpla2 / 780152	XenbaseID:	XB-GENE-953517	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	160/462 - (34%)
Similarity:	233/462 - (50%)	Gaps:	63/462 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFLRVV 70
            ::||:|||||||||:|||.||::|.|.|:  ...|.|||||||.|..|:....|.....:.:.|.
Frog     9 NISFAGCGFLGIYHIGVASCLKEHTPFLVENARNIYGASAGALTATALVSGACLGEAGANIIDVS 73

  Fly    71 QEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQEL 135
            :|.::..||...|.|||.:.:...:...||||||..|:|||.||||||||..||::|:|::::||
Frog    74 KEARKRFLGPLHPSFNLVKIIRNCLYKTLPEDAHEKATGRLGISLTRVSDGENVLLSQFNTKEEL 138

  Fly   136 LQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPLLD-EHTVTVSPFCGESDICPRDQNPHLL 199
            :||.:||.|||...||:||.::||||:||..|||||..: ::|:|||||.|||||||||...:|.
Frog   139 IQACVCSTFIPVYCGLIPPCLQGVRYVDGGISDNLPQYELKNTITVSPFSGESDICPRDGCTNLH 203

  Fly   200 QLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLNE-------GF 257
            :|.:  .||.|:.:..||.|:.:.|.|.....:.:.|:|||.|.|.||:||.|||.       ..
Frog   204 ELRV--TNTSIQFNLSNLYRLSKALFPPEPQVLKDMCKQGYRDALHFLKRNGLLNRPQPGRPLAL 266

  Fly   258 KIQEKGMISWIHQQMEREKELRETPRDLEKVHTNRMTTNNVQHKKRRNRKQRTQRQTLQRTKKNQ 322
            ...|.     |..:.|..:...|...|:..|..       .:.....:..||..:..|:..|:.
Frog   267 PAPEN-----IANENEASRNSEEPEDDIAAVQA-------AEDHIFEHLPQRLNQALLEACKEK- 318

  Fly   323 QEKIRNGRSLEMEIRNQEKNHQEST-----NSSVENLTPIAEKRLENRP--PEEHNHYGSSLMGS 380
                   ||:.:.|.|.......|.     ...:|:......:.||..|  ||:...    :...
Frog   319 -------RSMYLSISNLLPVRMASALMLPYTLPLESALSFTVRLLEWLPDVPEDIEW----IKDQ 372

  Fly   381 TWSLLRRVMFAPPLARHMVQVIARHLSQSLTLCDQPHFDLALMQAPAACHP---STTSCPP---- 438
            |..:.|.|:      |:..:.:..|::..|      ::.|.|.:|.:...|   |::.|.|
Frog   373 TRKVCRYVL------RNAKKQLGNHITARL------YYHLELRRAQSVTVPLTFSSSDCLPRWVR 425

  Fly   439 -STPLGD 444
             ||.|.|
Frog   426 TSTSLMD 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	119/247 (48%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674	19/111 (17%)
pnpla2	NP_001072695.1	Pat_PNPLA2	4..252	CDD:132859	117/244 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm9389
Panther	1	1.100	-	-	O	PTHR12406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160