DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dob and pnpla3

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001015693.1	Gene:	pnpla3 / 548410	XenbaseID:	XB-GENE-5855123	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	180/535 - (33%)
Similarity:	265/535 - (49%)	Gaps:	117/535 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLLLE--RIAGASAGALAACCLICDLPLECMAGDFLRVV 70
            :|||.||||||:|||||:.||::.||:|:.:  :|.|||||||.|..|:|...|.....|.|.|.
Frog     9 NLSFCGCGFLGVYHVGVSSCLQERAPRLITQANKIYGASAGALNAAALVCGCSLAQCCSDVLGVA 73

  Fly    71 QEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQEL 135
            :|.::.:||...|.|||.:.|.:|:...|||:||.||||:|.||||||||..||::|||:|::||
Frog    74 KEARKRNLGPLHPSFNLVKILKKGLYRNLPENAHELASGKLCISLTRVSDGENVLVSEFNSKEEL 138

  Fly   136 LQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPLLD-EHTVTVSPFCGESDICPRDQNP--- 196
            :|||:||.|:|...||:||..|||||:||..|:|||..| ::|:|||||.|||||||||.|.
Frog   139 IQALICSAFVPIYCGLIPPSFRGVRYVDGGISNNLPEYDLKNTITVSPFSGESDICPRDSNSTNF 203

  Fly   197 HLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLNEGFKIQE 261
            |.|::    .||.|:.|..||.|:.|.|.|.....:...|||||:|.|:||:.|:||:
Frog   204 HELRV----TNTSIQFSLGNLYRLTRALFPPEPTVLGEMCQQGYNDALRFLKDNNLLS------- 257

  Fly   262 KGMISWIHQQMEREKELRETPRDL------EKVHTNRMTTNNVQHKKRRNRKQRTQRQTLQ---- 316
                            |.....||      ....::.:|.:.....||  .::..:|:.|:
Frog   258 ----------------LPSPAADLCLAFPKATPLSHHLTCDCCVKSKR--EEEDLKRKVLEGPTP 304

  Fly   317 -RTKKNQQEKIRNGRSLEMEIRNQEKN---HQEST--------------NSSVENLTPIAEKRLE 363
             ...|...|::.......::...:|||   ||.|:              ...||::..:|.:.::
Frog   305 WSLDKRIMERLPPSLCYVLQEACREKNGLYHQISSLLPMRVASYMVMPYTLPVESVVSVALRLVD 369

  Fly   364 NRP--PEE---HNHYGSSLMGSTWS----------------LLRRVMFAPP-LARHMVQVIARHL 406
            ..|  ||:   ......|:.|:.:|                .||:.:..|| |.|....:...:.
Frog   370 WFPDMPEDMRWMQEQVRSVAGAVYSQAKKRLLPSVRSSGHGTLRKCLSLPPHLHRASSYLSPNNF 434

  Fly   407 SQSLTLCDQPHFDLALMQAPAACHPSTTSCP--------PSTPLGDSDNDKVKAQCV--CEASQI 461
            |.::.| :...||.              |||        |:.|..:.|:| .:.:|:  .|.|.:
Frog   435 SSAMDL-EGWVFDF--------------SCPSLLRDHQDPNDPQLELDSD-AQPKCIFSLEDSGV 483

  Fly   462 ------ESEDQVAEV 470
                  :.||..:|:
Frog   484 DVNFSTDPEDSASEL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	130/250 (52%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674	22/137 (16%)
pnpla3	NP_001015693.1	Pat_PNPLA2	4..253	CDD:132859	129/247 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm9389
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1585
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.070