DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dob and Pnpla1

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001030057.1	Gene:	Pnpla1 / 433091	MGIID:	3617850	Length:	599	Species:	Mus musculus

Alignment Length:	544	Identity:	146/544 - (26%)
Similarity:	224/544 - (41%)	Gaps:	130/544 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRRSLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFL 67
            |..|:||||.|||..|..|....||..||::|  ..|.||.||||:.|..::|.:.:|    .:|
Mouse    12 TPHSISFSGSGFLSYYQAGAVDALRDLAPRMLDTAHRFAGTSAGAVIAALVVCGIEME----KYL 72

  Fly    68 RVVQ----EIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSE 128
            ||:.    |:::..||..||...:.:.:.:.:...||||::..|:|:||:|||||:|..|||:||
Mouse    73 RVLNMGLAEVKKFFLGPLSPSCKMVQMMRQFLYDVLPEDSYKFATGKLHVSLTRVTDGENVVVSE 137

  Fly   129 FSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPL-LDEHTVTVSPFCGESDICPR 192
            :.|::||::||.||||:|...|.:||..||.||:||.|:...|. ....::|:|.|..:.|||||
Mouse   138 YRSKEELIEALYCSCFVPVYCGFIPPTYRGERYIDGGFTSMQPCSFWTDSITISTFSSQQDICPR 202

  Fly   193 DQNPHLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLNEGF 257
            | .|.:.. :....|...:.|..|:.||...|.|.....:..:..:||:|.:.:|||   ||..:
Mouse   203 D-CPTIFH-DFRMFNFSFQFSLENITRMTHALFPPDLVILQEYYYRGYNDAVSYLRR---LNAAY 262

  Fly   258 -------------KIQEKGMISWIHQ----QMEREKELRETPRDLEKVHTNRMTTNNVQHKKRRN 305
                         ::..:..::..|:    .::....||.:|.|..:.|...      ..||.|.
Mouse   263 LDSPSKRVIFPRVEVYCQIEVALGHEPPPPSLQNLPALRRSPADSSQTHAQG------SPKKDRK 321

  Fly   306 RKQRTQRQTLQRTKKNQQEKIRNGRSLEMEIR--------------------------------- 337
            ....:...::|..:...:|.:.:..||.:.|.
Mouse   322 DSHSSAAPSVQTPESGCKESVESPVSLRVSISKQPSVSPLSPAQPVPVMRPTGPRDSCPINVQTP 386

  Fly   338 NQEKNHQESTNSSVEN---------------------LTPIAEKR-------LENRPPEEHNHYG 374
            |.|:..:.:.:|:.|.                     |.|.|:.|       :....||......
Mouse   387 NPERGVKGALDSATERGMKDALASATDEQSTTTLPPVLLPAADSRGSKTGSSVPIGSPESPRLLL 451

  Fly   375 SSLMGSTWSLLRRVMFAPPLARHMVQVIARHLSQSLTLCDQPHFDL-----------ALMQAPAA 428
            .|..|:|.|  |..:..||            ||.|......|..||           ||.|...:
Mouse   452 RSSQGATAS--RATLGLPP------------LSPSTPPAGPPVEDLGPERPTATGSPALSQLTGS 502

  Fly   429 CHPSTTSCPPSTPL-----GDSDN 447
            ..|.|....|..||     |:..|
Mouse   503 AAPGTGKKAPHKPLLVEGPGEDSN 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	96/252 (38%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674	23/169 (14%)
Pnpla1	NP_001030057.1	Patatin_and_cPLA2	3..372	CDD:299702	113/374 (30%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	51..55		2/3 (67%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	172..174		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..563		46/258 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920