DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dob and Pnpla3

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001269253.1	Gene:	Pnpla3 / 362972	RGDID:	1595843	Length:	425	Species:	Rattus norvegicus

Alignment Length:	252	Identity:	117/252 - (46%)
Similarity:	166/252 - (65%)	Gaps:	5/252 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RRSLSFSGCGFLGIYHVGVAVCLRQHAPQLLLE--RIAGASAGALAACCLICDLPLECMAGDFLR 68
            |.||||:||||||.||:|..:||.:.||.:|.|  ...|.|||||.|...:|.|||:.:....:.
  Rat     7 RWSLSFAGCGFLGFYHIGATLCLSERAPHILREARTFFGCSAGALHAVTFVCSLPLDHIMEILMD 71

  Fly    69 VVQEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQ 133
            :|::.:..::|...|:||:.:|:.:|::..||::.|.:.||:::||||||||..||::|||.|:.
  Rat    72 LVRKARSRNIGTLHPFFNINKCVRDGLQETLPDNVHQIISGKVYISLTRVSDGENVLVSEFHSKD 136

  Fly   134 ELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPLLD-EHTVTVSPFCGESDICPRDQNPH 197
            |::.||:||||||..|||:||..||.||:||..|||:|:|| :.|:|||||.||.||||:.::.:
  Rat   137 EVVDALVCSCFIPLFSGLIPPSFRGERYVDGGVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTN 201

  Fly   198 LLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLN 254
            .||:||  .|..:||...||..:.|.|.|.....|...|.|||.|..:||..|.:.|
  Rat   202 FLQVNI--TNLSLRLCTGNLHLLTRALFPSDVKVMGELCFQGYLDAFRFLEENGICN 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	115/248 (46%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674
Pnpla3	NP_001269253.1	Patatin_and_cPLA2	8..259	CDD:299702	116/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3023
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm8965
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1585
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930