DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dob and PNPLA1

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_016866265.1	Gene:	PNPLA1 / 285848	HGNCID:	21246	Length:	581	Species:	Homo sapiens

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	235/517 - (45%)	Gaps:	86/517 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRRSLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFL 67
            |..|:||||.|||..|..|....||..||::|  ..|.||.||||:.|...||.:.::    ::|
Human    12 TPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICGIEMD----EYL 72

  Fly    68 RV----VQEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSE 128
            ||    |.|:::..||..||...:.:.:.:.:...||||::.:.:|:||:||||::|..|||:||
Human    73 RVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSE 137

  Fly   129 FSSRQELLQALMCSCFIPGLSGLVPPQVRGV---------RYMDGAFSDNLP-LLDEHTVTVSPF 183
            |:|::||::||.||||:|...||:||..|||         ||:||.|:...| ......:|:|.|
Human   138 FTSKEELIEALYCSCFVPVYCGLIPPTYRGVWAFLTLPPQRYIDGGFTGMQPCAFWTDAITISTF 202

  Fly   184 CGESDICPRDQNPHLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLR 248
            .|:.|||||| .|.:.. :....|...:.|..|:.||...|.|.....:.::..:||:|.:.:||
Human   203 SGQQDICPRD-CPAIFH-DFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYYRGYEDAVLYLR 265

  Fly   249 RNSLLNEGFKIQEKGMISWIHQQMEREKEL---RETPRDLEKVHTNRMTTNNVQHKKRRNRKQRT 310
            |   ||..:.......:.:...::..:.||   .|.|                   :|.....|.
Human   266 R---LNAVYLNSSSKRVIFPRVEVYCQIELALGNECP-------------------ERSQPSLRA 308

  Fly   311 QRQTLQRTKKNQQEKIRNG--------------RSLEMEIRN---------QEKNHQ---ESTNS 349
            ::.:|:...:..:|.:..|              ::||....:         ::...|   .||..
Human   309 RQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPL 373

  Fly   350 SVENLTPIAEKRLENRPPEEHNHYGSSLMGSTWSLLRRVMFAPPLARHMVQVI---ARHLSQSLT 411
            |:..:.|::...: ::||.  :..||||......|      :|...:..||..   ||.|.....
Human   374 SLSGMPPVSFPAV-HKPPS--STPGSSLPTPPPGL------SPLSPQQQVQPSGSPARSLHSQAP 429

  Fly   412 LCDQPHFDLALMQAPAACHPSTTSC-PPSTPLGDSDNDKVKAQCVCEASQIESEDQVAEVAE 472
            ...:|....:.:.||.....|:.|. |...|:.:...::.:|..:..:|:.:|...:..|.|
Human   430 TSPRPSLGPSTVGAPQTLPRSSLSAFPAQPPVEELGQEQPQAVALLVSSKPKSAVPLVHVKE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	99/261 (38%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674	18/133 (14%)
PNPLA1	XP_016866265.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880