DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dob and pnpla2

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_005174313.2	Gene:	pnpla2 / 101887155	ZFINID:	ZDB-GENE-120913-3	Length:	486	Species:	Danio rerio

Alignment Length:	332	Identity:	134/332 - (40%)
Similarity:	185/332 - (55%)	Gaps:	37/332 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFLRVV 70
            ::||:|||||||||:|||.||::|||.|:  ...|.|||||||.|..|:....|.....:.:.|.
Zfish     9 NISFAGCGFLGIYHIGVASCLQEHAPFLVENARHIYGASAGALTASALVTGACLGEAGANIIDVA 73

  Fly    71 QEIQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQEL 135
            :|.::..||...|.|||.:.:...:...:|.|.::.|:|||.||||||:|..||::|.|:|.:||
Zfish    74 KEARKRFLGPMHPSFNLVKIMRTHLHRVMPVDGYIRATGRLGISLTRVTDGENVLVSHFNSNEEL 138

  Fly   136 LQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLPLLD-EHTVTVSPFCGESDICPRD---QNP 196
            :||.:||.:||...||:||.::||||:||..|||||..: ::|:|||||.|||||||||   .|.
Zfish   139 VQACICSAYIPVYCGLIPPTLQGVRYVDGGISDNLPQYELKNTITVSPFSGESDICPRDVSSTNI 203

  Fly   197 HLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLRRNSLLN------- 254
            |    .:.:.||.|:.:..||.|:.|.|.|.....|.:.|:|||.|.|.||::|.||.
Zfish   204 H----ELRFTNTSIQFTLANLYRVSRALFPPDPLVMKSMCKQGYRDALLFLKKNGLLQYRGPHRA 264

  Fly   255 -----EGFKIQEKGMISWIHQQMEREKELRETPRDLEKVHTNRMTTNNVQHKKRRNRKQ-----R 309
                 ||...:..|      :..||..|......|    |.:.|..:..:|...|..|.     |
Zfish   265 LAAAAEGADEESDG------EDEERRDEGEPEADD----HRSSMEEHVFEHLPPRVHKALVEACR 319

  Fly   310 TQRQTLQ 316
            .:|..||
Zfish   320 ERRSLLQ 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	116/250 (46%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674	13/52 (25%)
pnpla2	XP_005174313.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2940
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm6600
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970