DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dob and pnpla4

DIOPT Version :9

Sequence 1:	NP_572995.1	Gene:	dob / 32436	FlyBaseID:	FBgn0030607	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_002939012.2	Gene:	pnpla4 / 100495026	XenbaseID:	XB-GENE-968680	Length:	271	Species:	Xenopus tropicalis

Alignment Length:	245	Identity:	96/245 - (39%)
Similarity:	148/245 - (60%)	Gaps:	6/245 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFLRVV 70
            :||||..|||||||:|.|..|.:|..::|  ::..||||||:|.|..|:........:.:||...
Frog    21 NLSFSASGFLGIYHLGAASALLKHGQKMLKYVKCFAGASAGSLVATVLLTAPDKIKESKEFLYAF 85

  Fly    71 QE-IQRHSLGAFSPWFNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQE 134
            .| :::..|||.:|.::..:.|..|:.|.||.:||.:|..||::|:|....|:|.::|.|:||:|
Frog    86 SEDVRKQKLGAMTPAYDFMKNLRGGIESILPVNAHEMAEHRLYVSITNAKSRKNCLVSHFASREE 150

  Fly   135 LLQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSDNLP-LLDEHTVTVSPFCGESDICPRDQNPHL 198
            |::.|:.|.::|..:|:.....:|.::.||.|:|:|| |.:..|:|||||.|..||||:|:  .|
Frog   151 LIKVLLASSYVPLYAGIKAVDYKGEKWFDGGFTDSLPHLPNGRTITVSPFSGRLDICPQDK--PL 213

  Fly   199 LQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQFLR 248
            ..|.:.:|...|.||..||||:.:.|.|.|.:.|....|.||.|.:.||:
Frog   214 WDLYVTFAKHSILLSEANLRRLNQALFPPRQEKMEAIFQDGYKDAVNFLQ 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dob	NP_572995.1	Pat_iPLA2	7..253	CDD:132857	96/245 (39%)
dob	NP_572995.1	EIN3	<270..>375	CDD:296674
pnpla4	XP_002939012.2	Pat_PNPLA4	21..266	CDD:132861	96/245 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17075
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950