DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opm and ERP4

DIOPT Version :9

Sequence 1:	NP_572994.1	Gene:	opm / 32435	FlyBaseID:	FBgn0264389	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_014659.1	Gene:	ERP4 / 854181	SGDID:	S000005542	Length:	207	Species:	Saccharomyces cerevisiae

Alignment Length:	226	Identity:	52/226 - (23%)
Similarity:	101/226 - (44%)	Gaps:	37/226 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVLLLSIAALLLGVQDAEAYDKE---MTVYVDAGKTECLYHSVRQG-ETIDFEYQVIDGGHGDLD 71
            |:.:|..::||     ..|:...   :.:.:.|...||||:.:... :.:...|||:.||:.::|
Yeast     6 LIAILFSSSLL-----THAFSSNYAPVGISLPAFTKECLYYDLSSDKDVLVVSYQVLTGGNFEID 65

  Fly    72 ISFTLLDPIGLVIVSDFKKPENVHRHEVAKE---GDYRFCFDNSFSMFNRKTVFFELIVEREGEE 133
              |.:..|.|.|||::.:|.   |...:.|.   |.|.||..|::....:|.   |:.:|:|.|.
Yeast    66 --FDITAPDGSVIVTERQKK---HSDFLLKSFGIGKYTFCLSNNYGTSPKKV---EITLEKEKEI 122

  Fly   134 LQGDTQWNEADELTGLSRDEYYDMKVQDIMDFIGRIRLQLTKARQLQDVLRSHEARDRNLAESNF 198
            :.              |.:...|:...:.::.|.|   .|.|..:..|.||:.|.|:.....|..
Yeast   123 VS--------------SHESKEDIIANNAIEEIDR---NLNKITKTMDYLRAREWRNMYTVSSTE 170

  Fly   199 QKVNHWSMVQISAMIGVGLIQVFMLRSIFAT 229
            .::...|::.:..|:|:.::|..:::..|.:
Yeast   171 SRLTWLSLLIMGVMVGISIVQALIIQFFFTS 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opm	NP_572994.1	EMP24_GP25L	33..227	CDD:279450	46/200 (23%)
ERP4	NP_014659.1	EMP24_GP25L	29..199	CDD:395878	46/194 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346450
Domainoid	1	1.000	62	1.000	Domainoid score	I2479
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1757
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	1	1.000	-	-		oto100299
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880