DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opm and Tmed5

DIOPT Version :9

Sequence 1:	NP_572994.1	Gene:	opm / 32435	FlyBaseID:	FBgn0264389	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_083152.1	Gene:	Tmed5 / 73130	MGIID:	1921586	Length:	229	Species:	Mus musculus

Alignment Length:	225	Identity:	92/225 - (40%)
Similarity:	140/225 - (62%)	Gaps:	9/225 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IWLGMPGLVLLLSIAALLLGVQD-AEAYDKEMTVYVDAGKTECLYHSVRQGETIDFEYQVIDGGH 67
            :||..|.|:|....||||.|... ..:.|.:.|..:.||:.||.|..:....:::.||||:||
Mouse     5 MWLPFPVLLLSALPAALLRGAAGFTPSLDSDFTFTLPAGRKECFYQPMPLKASLEIEYQVLDG-- 67

  Fly    68 GDLDISFTLLDPIGLVIVSDFKKPENVHRHEVAKEGDYRFCFDNSFSMFNRKTVFFELIVEREGE 132
            |:|||.|.|..|.|..:|.:.:|.:.||..| .::|||.|||||:||..:.|.:|||||::..||
Mouse    68 GELDIDFHLTSPEGRTLVFEQRKSDGVHTIE-TEDGDYMFCFDNTFSTISEKVIFFELILDNMGE 131

  Fly   133 ELQGDTQWNEADELTGLSRDEYYDMKVQDIMDFIGRIRLQLTKARQLQDVLRSHEARDRNLAESN 197
            |:||...|.:.     ::..:..:||::||::.|..|:.:|:|:..:|.:||:.||||||:.|||
Mouse   132 EVQGQEDWKKY-----ITNTDVLEMKLEDILESINSIKSRLSKSGHIQTLLRAFEARDRNIQESN 191

  Fly   198 FQKVNHWSMVQISAMIGVGLIQVFMLRSIF 227
            |.:||.||:|.:..|:.|..|||:.|:|:|
Mouse   192 FDRVNFWSVVNLMVMVVVSAIQVYTLKSLF 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opm	NP_572994.1	EMP24_GP25L	33..227	CDD:279450	80/193 (41%)
Tmed5	NP_083152.1	EMP24_GP25L	35..222	CDD:279450	81/195 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3945
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4996
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4053
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49398
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	1	1.000	-	-		mtm8870
orthoMCL	1	0.900	-	-		OOG6_108563
Panther	1	1.100	-	-	O	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	1	1.000	-	-		X1510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860