DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment opm and TMED5

DIOPT Version :9

Sequence 1:	NP_572994.1	Gene:	opm / 32435	FlyBaseID:	FBgn0264389	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_057124.3	Gene:	TMED5 / 50999	HGNCID:	24251	Length:	229	Species:	Homo sapiens

Alignment Length:	225	Identity:	93/225 - (41%)
Similarity:	135/225 - (60%)	Gaps:	9/225 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IWLGMPGLVLLLSIAALLLGVQD-AEAYDKEMTVYVDAGKTECLYHSVRQGETIDFEYQVIDGGH 67
            |||..|.|:|......||.|... ..:.|.:.|..:.||:.||.|..:....:::.||||:||
Human     5 IWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQVLDG-- 67

  Fly    68 GDLDISFTLLDPIGLVIVSDFKKPENVHRHEVAKEGDYRFCFDNSFSMFNRKTVFFELIVEREGE 132
            ..|||.|.|..|.|..:|.:.:|.:.||..| .:.|||.|||||:||..:.|.:|||||::..||
Human    68 AGLDIDFHLASPEGKTLVFEQRKSDGVHTVE-TEVGDYMFCFDNTFSTISEKVIFFELILDNMGE 131

  Fly   133 ELQGDTQWNEADELTGLSRDEYYDMKVQDIMDFIGRIRLQLTKARQLQDVLRSHEARDRNLAESN 197
            :.|....|.:  .:||   .:..|||::||::.|..|:.:|:|:..:|.:||:.||||||:.|||
Human   132 QAQEQEDWKK--YITG---TDILDMKLEDILESINSIKSRLSKSGHIQTLLRAFEARDRNIQESN 191

  Fly   198 FQKVNHWSMVQISAMIGVGLIQVFMLRSIF 227
            |.:||.||||.:..|:.|..|||:||:|:|
Human   192 FDRVNFWSMVNLVVMVVVSAIQVYMLKSLF 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opm	NP_572994.1	EMP24_GP25L	33..227	CDD:279450	82/193 (42%)
TMED5	NP_057124.3	EMP24_GP25L	35..222	CDD:279450	83/195 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4153
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4996
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4166
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49398
OrthoDB	1	1.010	-	-		D1292519at2759
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	1	1.000	-	-		mtm8638
orthoMCL	1	0.900	-	-		OOG6_108563
Panther	1	1.100	-	-	O	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	1	1.000	-	-		X1510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870