DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment opm and TMED6

DIOPT Version :9

Sequence 1:	NP_572994.1	Gene:	opm / 32435	FlyBaseID:	FBgn0264389	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_653277.2	Gene:	TMED6 / 146456	HGNCID:	28331	Length:	240	Species:	Homo sapiens

Alignment Length:	243	Identity:	60/243 - (24%)
Similarity:	95/243 - (39%)	Gaps:	49/243 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLVLLLSIAAL-------LLGVQD------AEAYDKEMTVYVDAGKTECLYHSVRQGETIDFEYQ 61
            |||:|..:.:.       |.|..|      |:.||  ..:.:..|.|||.:....|.....|.|:
Human     9 GLVVLNLVTSARSQKTEPLSGSGDQPLFRGADRYD--FAIMIPPGGTECFWQFAHQTGYFYFSYE 71

  Fly    62 V---IDGGHGDLDISFTLLDPIGLVIVS--------DFKKPENVHRHEVAKEGDYRFCFDNSFSM 115
            |   :...| |..::.|..:|.|.:|.:        :|...|.         |.|:.|..|..:.
Human    72 VQRTVGMSH-DRHVAATAHNPQGFLIDTSQGVRGQINFSTQET---------GFYQLCLSNQHNH 126

  Fly   116 FNRKTVFFELIVEREGEELQGDTQWNEADELTG-LSRDEYYDMKVQDIMDFIGRIRLQLTKARQL 179
            |....|:....|..||.|.  |.:..|..:|.. |...|....|||:.:..:.|. ....:.|::
Human   127 FGSVQVYLNFGVFYEGPET--DHKQKERKQLNDTLDAIEDGTQKVQNNIFHMWRY-YNFARMRKM 188

  Fly   180 QDVLRSHEARDRNLAESNFQKVNHWSMVQISAMIGVGLIQVFMLRSIF 227
            .|..         |.:||:..||.||..|...:|..|::|::.|:.:|
Human   189 ADFF---------LIQSNYNYVNWWSTAQSLVIILSGILQLYFLKRLF 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
opm	NP_572994.1	EMP24_GP25L	33..227	CDD:279450	49/205 (24%)
TMED6	NP_653277.2	EMP24_GP25L	43..228	CDD:279450	51/209 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810